Acta Obstetricia Et Gynecologica Scandinavica

Joelsson, Ingemar; Odeblad, Erik

doi: 10.3109/00016347209156862pmid: 4642715

A method for determining small rates and fluctuations of flow has been applied to the uterine secretions in non‐pregnant women, the secretions being labelled by added heat, 4·10−3 cal·sec−1. Base line secretory rates during consecutive phases of the menstrual cycle were determined but the main advantage of the technique is the unique possibility of studying fluctuations in the rate of flow as a measure of uterine motility, without interference from foreign bodies in the uterine cavity. The responses of the non‐pregnant human uterus in vivo to intravenously injected synthetic oxytocin and to the deposition of fluid in the posterior fornix are reported.

Bock, Johannes E.; Wiese, J.

doi: 10.3109/00016347209156863pmid: 4642716

Two series of cases of umbilical cord prolapse are submitted. One comprises 97 cases and the other 64. The total corrected mortality rate was 13.0% and 34.5% respectively, the mature corrected mortality rate 1.5% and 20.0%. The total mortality for breech presentations with prolapsed cord was 19.2% and 23.8% respectively. In cephalic presentations the mortality rate was 10.3% and 54.3% respectively. This difference in mortality is explained by a more active attitude in the department having the lower mortality, where the diagnosis was more often made by vaginal examination, the delivery was more rapid, and the use of Caesarean section more common.

Höglund, Astrid; Joelsson, Ingemar; Ingelman‐sundberg, Axel; Odeblad, Erik

doi: 10.3109/00016347209156864pmid: 4674549

With the ultimate purpose of evaluating the accuracy and specificity of the fluorescence of acridine orange stained cells or tissues as a sign of malignancy, this compound and its binding to stain receptors have been studied with biophysical methods. The present paper describes the identification of the lines in the proton magnetic resonance spectrum of acridine orange zinc trichloride. The ring proton lines are weak but the methyl line is strong and easy to record with a high ratio of the signal‐to‐background noise. The methyl line is composed of two superimposed parts, one narrow and one broad, with the same chemical shift. The reason why the methyl line is divided into components is, however, still unknown.

Larsson‐cohn, Ulf; Fagerhol, Magne K.; Abildgaard, Ulrich

doi: 10.3109/00016347209156865pmid: 4642717

Oral contraceptive treatment with a low daily dose of Norethindrone did not lower the Antithrombin‐III level in serum. This was in contrast to what was found in subjects taking estrogen‐progestogen agents.

Nielsen, F. Hassing

doi: 10.3109/00016347209156866pmid: 4642718

A series of 25 healthy women, 13 of whom had a tendency to diabetes, was studied for 5 consecutive menstrual cycles, with regard to the effect of a combined oral contraceptive containing O.S mg norgestrel and 0.05 mg ethinylestradiol (Eugynon®) on the carbohydrate metabolism. The following tests were performed on these women at midcycle in the cycle prior to, in the two cycles during, and in the second cycle after administration of the drug: Fasting blood sugar, i.v. glucose‐tolerance, fasting insulin and insulin response to i.v. glucose injection. The drug was administered daily from the fifth to twenty‐fifth day of cycles two and three. Thus each subject served as her own control.

Åstedt, Birger

doi: 10.3109/00016347209156867pmid: 4642719

The content of fibrinolytic enzymes in the vessel walls in the puerperium was determined histochemically in biopsy specimens of hand veins and the release of such enzymes into the blood stream was studied after stimulation by venous occlusion of the arms. The local response of the fibrinolytic activity in the blood to such venous occlusion, which is known to be decreased during pregnancy, was almost normal as early as two hours post parlum. The fibrinolytic activity in the vessel wall was found to be normal on the 2nd‐5th day post parlum. The early return of the fibrinolytic activity in the blood and in the vessel wall is probably due to loss of the influence of placental hormones and perhaps also to the loss of a placental inhibitor of fibrinolysis.

Rydén, Gunnar

doi: 10.3109/00016347209156868pmid: 4642720

Using a new method for estimation of cystine aminopeptidase (CAP) activity in maternal serum, serial CAP determinations have been performed in 7 women during normal pregnancy, in 7 patients after delivery, in 10 patients with pre‐eclampsia, in 5 patients with suspected placental insufficiency and in 4 multiple pregnancies. The results were as follows.

Ulstein, Magnar

doi: 10.3109/00016347209156869pmid: 4642721

Semen samples were examined from 51 fertile men, and from the male partners in 283 infertile marriages. In addition to routine analysis, they were tested for sperm penetration through ovulatory cervical mucus, using the method of Kremer with slight modifications. Comparison of the 2 groups in regard to semen properties showed statistically significant differences between the means for density, percentage of living, motile and abnormal spermatozoa, for motility degree, and for sperm penetration. No significant difference between the means was found for volume, content of fructose and acid phosphatase in the seminal plasma. In the entire series a moderate correlation was found between sperm penetration and percentage of motile spermatozoa, motility degree, density, percentage of living and percentage of abnormal spermatozoa. A low correlation was found between sperm penetration and volume, content of fructose or acid phosphatase in seminal plasma. The variance of sperm penetration due to regression of the other semen properties was only 43%. Sperm penetration had the highest discriminant function coefficient of the tested semen properties. Semen samples from fertile men had high penetration values although other semen properties were sometimes pathological. The sperm penetration test is a most valuable supplement to routine semen analysis for male fertility estimation.

Starup, Jørgen

doi: 10.3109/00016347209156870pmid: 4642722

Investigation of 31 patients who developed amenorrhoea following the use of combined oral contraceptives for a period of 3 to 84 months revealed that 55% had a variable degree of oligomcnorrhoea prior to the treatment. It is therefore concluded that an antecedent menstrual dysfunction is a relative contra‐indication to treatment with combined oestrogen‐gestagen preparations, and that another form of contraception should be recommended in these cases.

Rybo, Göran; Westerberg, Hans

doi: 10.3109/00016347209156871pmid: 4566005

A double blind randomized trial was made to ascertain the effect of tranexamic acid (AMCA) (Cyklo‐kapron®) on the postoperative blood loss after conization. The case material consisted of 50 women referred to the clinic because of dysplasia or non‐invasive cancer of the cervix. Five patients were excluded for various reasons. The treatment started in the evening of the day of operation and was continued for another 12 days, the dose being three tablets every 8 hours, corresponding to 4.5 g of tranexamic acid daily when the active drug was given. During the first 7 postoperative days, when the patients were in hospital, the blood losses were determined quantitatively. Prophylactic treatment with tranexamic acid reduced the postoperative blood loss as compared with the placebo group, the blood losses being 23 ± 3.2 ml and 79 ± 20.4 ml respectively. Sudden profuse bleeding postoperatively, requiring remedial measures, occurred in 7 patients, all in the placebo group. With the exception of 1 patient in the placebo group, who complained of nausea, no side effects were recorded.