Serum Lipids and Fatty Acid Composition of Serum Lecithin in the Non‐Pregnant State in Patients with Previous Cholestasis of PregnancySamsioe, Göran
doi: 10.3109/00016347609156775pmid: 1251687
Abstract. Serum lipids and fatty acid composition of serum lecithin were studied 8‐21 months after delivery in 20 non‐pregnant women who during their latest pregnancy had presented signs of CP. These women were compared with normal non‐pregnant women (n = 18) and with patients with cholestasis of pregnancy (CP) (n = 28). In the non‐pregnant state women with previous cholestasis of pregnancy (CP) showed in serum lecithin a low relative content of palmitic (16:0) and linoleic (18:2) acids and a high portion of stearic acid (18:0). These findings indicate as a basic defect in CP, a reduction in liver lecithin synthesis via pathway I (Kennedy's pathway) in favour of an increased pathway II (Greenberg's pathway). These data further support the hypothesis of increased estrogen activity as an etiological factor in CP. The basic influence by pregnancy on serum lipids and serum lecithin fatty acid composition was the same in women with CP as in women with a normal pregnancy.
Urography and Renography in the Follow‐Up of Patients with Toxemia of Late PregnancyPystynen, P.; Laitinen, S.; Makkonen, M.; Penttilä, I. M.
doi: 10.3109/00016347609156776pmid: 1251695
Abstract. We have studied 129 patients with toxemia of pregnancy two months post partum by urography and renography. The same investigations were performed on 17 healthy parturients post partum. 49 patients (38.8%) had an abnormality either in urography or renography. 20 patients (15.5%) had an abnormal urogram and 42 (32.6%) an abnormal renogram. The findings correlated so that 7 patients had an abnormal urogram with a normal renogram and 13 patients had an abnormality in both investigations. 29 patients had only an abnormal renogram. In the control series 3 patients had an abnormal urogram and the same patients also had an abnormal renogram. We divided the studied patients into groups according to the lcinical severity of toxemia. Urographic and renographic findings were divided evenly in the series so that abnormalities were no more common in the severe cases. Renography cannot be considered merely as a screening method when compared with urography in the follow‐up of toxemic patients, but these investigations are complementary.
Decrease in the Mortality Rates for Low‐Birth‐Weight Infants After Phenobarbitone TreatmentTrolle, Dyre
doi: 10.3109/00016347609156777pmid: 1251688
Abstract. A daily dosage of 100 mg phenobarbitone administered orally to pregnant women for three days or more immediately before delivery has reduced the various mortality rates for low‐birth‐weight infants by 50% or more. Since it is hardly possible to treat all pregnant women in this way it is recommended to administer phenobarbitone to women with high‐risk pregnancies such as former stillborn infant, former premature delivery, pregnancy complications, and planned induction of premature labour before the 37th week and until delivery takes place. If the mothers of low‐birth‐weight infants have not been adequately treated it is recommended that the newborn infant be given phenobarbitone injections immediately after birth and at 8‐hour intervals, 10 injections in all.
Blood Flow in Myomatous Uteri as Measured by Intra‐Arterial 133XenonForssman, Lars
doi: 10.3109/00016347609156778pmid: 1251689
Abstract. Uterine blood flow has been studied using intra‐arterial 133Xenon. Compartment analysis was used for calculation of blood flow from the wash‐out curves. In 7 myomatous uteri the mean blood flow was 11.6·1.70 ml·min−1· 100 g−1. In 8 control cases the mean blood flow was 20.1·2.27 ml·min−1· 100 g−1. The difference is statistically significant on the 1% level. From the present study it cannot be decided how the uterine blood flow is distributed between myomata and surrounding myometrium.
A Prospective Study of Drugs and Pregnancy: I. PsychopharmacaKullander, Stig; Källén, Bengt
doi: 10.3109/00016347609156779pmid: 1251690
Abstract. A prospective study has been performed on the use of psychopharmaca during 6376 pregnancies and its correlation to certain socio‐medical variables and pregnancy outcome. An association between drug use and later miscarriage or legal abortion was demonstrated and is conceivably due to an increased use of such drugs in unwanted pregnancies. No indication of an association between drug use and birth of a dead or defective infant was found. Pregnancies where psychopharmaca were used during the first trimester had, on average, a longer duration than pregnancies where such drugs were not used, but birth weight of full‐term infants was not affected.
Disc‐Electrophoretic Protein Pattern of Cervical Mucus in Cases of Humoral Sensitization Against SpermatozoaMettler, L.; Gradl, T.; Mäder, Ch.
doi: 10.3109/00016347609156780pmid: 1251691
Abstract. Midcycle cervical mucus samples from 20 fertile women with negative, and from 6 infertile women with positive serum‐sperm agglutinating activity were subjected to a qualitative protein analysis by the Ouchterlony‐technique, to polyacrylamide (PAA) discelectrophoresis and after purification on spermatozoa they were also run against rabbit antihuman serum in the Laurell immuno‐electrophoretic technique. By the Ouchterlony method the main serum protein fractions were shown to occur also in cervical mucus. No significant differences could be found in the protein pattern of samples from fertile and infertile females as detected by polyacrylamide (PAA) electrophoresis. In all samples a split protein fraction corresponding to serum albumin and a band preceding the protein fraction corresponding to serum prealbumin were observed. In 2 samples from infertile females it could be demonstrated that immunoglobulins occurring in the cervical mucus were directed towards antigenic sperm components.
Study of the Suppression of Lactation and the Influence on Blood Clotting with Bromocriptine (Cb 154) (Parlodel®): A Double Blind Comparison with DiethylstilboestrolNilsen, P. A.; Meling, Anne‐Berit; Abildgaard, U.
doi: 10.3109/00016347609156781pmid: 766555
Abstract. Inhibition of lactation was studied in 38 puerperal women in a double blind trial to assess the effect of bromocriptine in comparison with diethylstilboestrol (DS). Simultaneously the influence of both compounds on blood clotting was studied, along with a control group of 20 women not receiving any medication. Bromocriptine was given in a daily dose of 5 mg for 14 days and DS in a daily dose of 20 mg for 7 days followed by a placebo for a further 7 days. The first doses were not later than 8 hours after delivery. Both compounds showed an inhibitory effect on the onset of lactation and mammary congestion. This inhibitory effect on both parameters was significantly in favour of bromocriptine during the last days of the treatment due to rebound in the DS group. The bromocriptine doses used (5 mg daily for 2 weeks) caused no objective side effects and no subjective restraint. Treatment with bromocriptine caused no untoward effect on the blood clotting, while in the DS group a slower return to normal antithrombin III could be observed. Also in this group one case of thrombophlebitis occurred. Bromocriptine can be administered to puerperal women for the suppression of lactation.
Growth of the Fetal Skull, with Special Reference to Weight‐For‐Dates of the Newborn ChildBergsjø, Per; Bakke, Trygve; Bjerkedal, Tor
doi: 10.3109/00016347609156784pmid: 1251694
Abstract. Two growth curves of the fetal biparietal diameter are presented. One is prospective, based on the last menstrual period, while the other is retrospective, calculated from the date of birth. The prospective curve shows a slight decline in average values following the week 42 of gestation. This is thought not to reflect a true shortening of the biparietal diameter in the single fetus, since serial measurements in single fetuses show growth up to the time of delivery. Individual growth curves, grouped according to the weight‐for‐dates of the newborn child, show a trend towards longer biparietal diameters in the larger fetuses. Serial measurements, preferably starting before week 30, appear to be a good help in predicting birth weight, but growth rates without regard to the actual measurement values were of little prognostic value in the present material.