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Taub, Arthur ; Hoffert, Marvin ; Kitahata, Luke M.
doi: N/Apmid: N/A
The effect of 75 per cent nitrous oxide–oxygen upon the spontaneous unit activity of cells in Rexed laminae IV, V, and VI of the dorsal horn of spinal cats was analyzed quantitatively with the aid of several digital computer programs. Overall statistical parameters, interval histograms, and burst-interval histograms were derived. Each cell lamina was characterized by a “statistical signature.” The spontaneous activity of lamina IV cells remained unaffected by the gas. The spontaneous activity of lamina V cells showed an increase in mean interval, accounted for by an increase in interburst interval, with relative maintenance of intraburst interval duration. The spontaneous activity of lamina VI cells was increased in rate and regularized in pattern. The cellular effects of analgesic agents cannot be described by overall statistical parameters alone, but require specification of the interval “fine structure” of spontaneous unit activity.
Orkin, Fredrick K.; Wollman, Harry
doi: N/Apmid: N/A
Hitt, Ben A.; Mazze, Richard I.; Cousins, Michael J.; Edmunds, Henry N.; Barr, Gary A.; Trudell, James R.
doi: N/Apmid: N/A
The metabolism of isoflurane was studied in Fischer 344 rats and man. In both species, ionic fluoride and non-ionic fluoride were detected in urine, with ionic fluoride the principal metabolite in rats and non-ionic fluoride the predominant end-product in man. Thin-layer chromatography indicated that the non-ionic fluoride metabolite was trifluoroacetic acid (TFA).
doi: N/Apmid: N/A
X-rays of human subjects show that the thyroid cartilage can undergo bending in association with several functional states of the larynx. Flexibility of the laminae appears to augment the opening effect of the sternothyroid or the closing effect of the thyrohyoid muscle on the air passage, and produces spring-actuated restitution of the passage when these muscles relax.
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