Etiologic Studies of Old Dog EncephalitisLincoln, S. D.; Gorham, J. R.; Ott, R. L.; Hegreberg, G. A.
doi: 10.1177/030098587100800101pmid: 4945659
In 2 cases of old dog encephalitis (ODE), viral antigen to canine distemper was demonstrated in frozen brain tissue by means of the direct FA test. The distemper viral antigen was most abundant in cells of the gray matter of the cerebral cortex, thalamus, mesencephalon, and medulla. Also, in the 1 dog in which serum was available, there was a significantly elevated serum antibody titer to the distemper agent. Attempts to isolate a viral agent in tissue culture or to transmit disease to distemper-susceptible ferrets or distemper-immune adult dogs were unsuccessful.Results of this study indicate that the virus of distemper play a role in the pathogenesis of ODE. Also, the progressive disease with inflammatory reaction suggests that a slow viral infection rather than a totally masked or latent virus be involved.
Calcitonin Activity in Ultimobranchial Neoplasms from BullsYoung, D. M.; Capen, C. C.; Black, H. E.
doi: 10.1177/030098587100800104pmid: 5168252
Ultimobranchial neoplasms from 5 bulls (hat were extracted and assayed individually contained approximately 68% as much calcitonin activity (452 ± 68 MRC mU/g) as thyroid glands from control bulls (663 ± 165 MRC mU/g). These results were consistent with the ultrastructural finding that thyroid neoplasms in old bulls were composed of primitive ultimobranchial cells which contained few mature secretory granules characteristic of parafollicular (C-) cells. Significant difference in calcitonin concentration was not detected between thyroid glands of control cows (617 ± 106 MRC mU/g) and bulls without ultimobranchial neoplasms.
Ophthalmic Lesions in Non-Human PrimatesSchmidt, R. E.
doi: 10.1177/030098587100800105pmid: 5003377
Over a 2-year period a number of spontaneous ophthalmic lesions were noted in non-human primates. These included lesions in baboons, old world monkeys, and chimpanzees. The lesions were divided into general etiologic categories of congenital, inflammatory, traumatic, degenerative, and undetermined. Specific lesions included colobomas, cataracts, detached retina, iridocyclitis, and morphologic changes due to myopia. Clinical and gross and/or histologic descriptions of the lesions were given, and their relative importance in a colony situation was described.
Lesions in Puppies Surviving Infection with Canine HerpesvirusPercy, D. H.; Carmichael, L. E.; Albert, D. M.; King, J. M.; Jonas, A. M.
doi: 10.1177/030098587100800106pmid: 4333733
Four puppies experimentally infected with canine herpesvirus (CHV) and one spontaneously infected animal, all of which survived the disease, were examined. Histologically, there were a focal granulomatous encephalitis, interstitial pneumonitis, and segmental renal necrosis with dysplasia. In the animal with naturally occurring infection there was segmental cerebellar and retinal dysplasia, and CHV antigen was demonstrated in the cerebellar cortex by fluorescence microscopy. The cerebellar and retinal dysplasia indicate that CHV can impair the differentiation of such tissues.
Streptococcal Bacterial Endocarditis in ChickensJortner, B. S.; Helmboldt, C. F.
doi: 10.1177/030098587100800107pmid: 5003378
Nineteen of 20 chickens with bacterial endocarditis characterized by well-developed vegetations on valves of the left side of the heart had lesions in the central nervous system. Anhemolytic streptococci were implicated as etiologic agents in 11 spontaneous cases, and S. faecalis var. liquefaciens was used to produce the disease experimentally in the 9 other birds. The CNS lesions were related to bacterial emboli, and included multifocal segmental inflammation of arteries, arterioles, and capillaries, with associated perivascular and intracerebral inflammatory foci, infarcts of brain tissue, and leptomeningitis.
The Histopathology of MaediGeorgsson, G.; Pálsson, P. A.
doi: 10.1177/030098587100800108pmid: 5157932
The histopathology of natural and experimental maedi, a slow-viral pneumonia of sheep, was studied. The main histological features are chronic interstitial inflammation with dense cellular infiltration, hyperplasia of smooth musculature in alveolar septa, and slight fibrosis; peribronchial and perivascular lymphoid hyperplasia, and epithelial proliferation in small bronchi and bronchioles accompanied in far advanced cases by epithelialization of the alveoli.The histopathology of maedi bears a close resemblance to pulmonary diseases of sheep reported under different terms in various parts of the world.
Proliferative Lesions of Serous Membranes in Ovariectomised Female and Entire Male Dogs After Stilboestrol AdministrationO'Shea, J. D.; Jabara, Anne G.
doi: 10.1177/030098587100800109pmid: 5157933
It was shown previously that ovarian tumours, which frequently metastasise to serous surfaces, can be produced in dogs by prolonged administration of stilboestrol.The ability of non-ovarian serous surfaces to proliferate in response to stilboestrol, independently of ovarian metastases, was studied in 5 ovariectomised females and 4 entire males. Papillary proliferations occurred on the uterine serosae in 3 females and on the testicular and cpididymal serosae in 2 males. In no case was there papillary proliferation on serous membranes of non-genital organs. One of 2 entire females given stillboestrol had proliferations regarded as metastases of ovarian origin on non-genital serous membranes.It is concluded that, in addition to ovarian changes, stilboestrol can cause primary proliferative lesions in the serous membranes of certain genital organs in both sexes. There is no evidence that serous membranes of non-genital organs be capable of a primary proliferative response to stilboestrol.
Choroid Plexus Papilloma in a DogKurtz, H. J.; Hanlon, Griselda F.
doi: 10.1177/030098587100800110pmid: 5157934
A 6-year-old female Cocker Spaniel with a choroid plexus papilloma had clinical signs of disease of the central nervous system for 1 month. The neoplasm originated from the right choroid plexus of the fourth ventricle and had displaced contiguous parts of the medulla oblongata and cerebellum. It was well differentiated and was composed of papillae arranged in an arboriform pattern. The papillae were lined by a single layer of non ciliated epithelium.