Structure of Cultured Fibroblasts from Dermatosparaxic CalvesYaeger, J. A.; Church, R. L.; Tanzer, M. L.
doi: 10.1177/030098587501200104pmid: 170727
Clonal cell lines from the dermis of a dermatosparaxic calf were grown in tissue culture. After fixation in a mixture of glutaraldehyde and osmium, they were prepared for electron microscopy. Most cells contained a well-developed Golgi region, lysosomes, mitochondria, and dilated cisternae of rough endoplasmic reticulum. They also contained numerous, large bundles of intracellular filaments, many lipid droplets and extensive arrays of vesicles. Cultures accumulated substantial amounts of extracellular fibrillar material. The fibrils were loosely packed and indistinctly cross-banded. Bundles of intracellular filaments were commonly parallel in adjacent cells and also parallel to extracellular fibrils. These cytoplasmic features may result from the inability of the secreted collagen to form normal fibrils.
Endometrial Stromal Tumor in a ChimpanzeeToft, J. D.; Kenzie, W. F. Mac
doi: 10.1177/030098587501200105pmid: 1166571
A 25-year-old female chimpanzee with disseminated tuberculosis also had two uterine tumors. One was a typical leiomyoma and the other, which occluded the uterine lumen, was composed of cells resembling normal endometrial stroma in its proliferative phase. It was diagnosed as an endometrial stromal tumor and was similar to that which occurs in the human female. This is the first report of this lesion in a nonhuman primate.
Spontaneous Lesions in the Aorta of the Common Brown Hare (Lepus europaeus)Wright, L. J.
doi: 10.1177/030098587501200106pmid: 1166572
The intimal surface of the aortic arch of 16 of 20 male common brown hares and 10 of 14 females had raised pale yellow to grey-white plaques up to 6 mm in diameter. These lesions were characterised by necrosis and calcification mainly in the tunica media and were not related to the age of the hares. In the hare this vascular disease may develop after injury to the connective tissue during obliteration of the ductus arteriosus. Although these aortic lesions were not the ‘spontaneous’ atherosclerotic variety they were morphologically similar to those in rabbits.
The Etiology of Swine DysenteryMeyer, R. C.; Simon, J.; Byerly, C. S.
doi: 10.1177/030098587501200107pmid: 1167199
A disease resembling swine dysentery occurred in gnotobiotic piglets previously colonized with Escherichia coli and given a mixture of five enteric anaerobes and spirochete B-78, orally. No disease occurred in germ-free piglets exposed to four Gram-negative obligate anaerobes or to the spirochete; however, if the four respective anaerobes were introduced into gnotobiotic pigs previously colonized with the spirochete, or when the spirochete was introduced into gnotobiotic pigs colonized with the anaerobes, a disease occurred that simulated swine dysentery. Swine dysentery is probably caused by the specific interaction of one or more enteric Gram-negative obligate anaerobes and a spirochete.