In conversation with Ukpong EyoFloriddia, Elisa
doi: 10.1038/s41593-023-01532-zpmid: 38052908
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved, and where it is heading. This month, we are talking to Ukpong Eyo (Associate Professor of Neuroscience at the University of Virginia, USA), a glial biologist interested in the role of microglia in neurodevelopment, health and disease, about science, family, and the benefits of finding your balance.
In conversation with Kelsey MartinWiseman, Shari
doi: 10.1038/s41593-023-01533-ypmid: 38052909
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. This month we are talking to Kelsey Martin, Executive Vice President of Autism and Neuroscience at the Simons Foundation and Professor in the Department of Biological Chemistry at the University of California, Los Angeles (UCLA), where she previously served as the Dean of the David Geffen School of Medicine. We discussed the pleasures of studying neuronal cell biology and her leadership roles.
Daily feeding entrains hunger-sensing neuronsAndrews, Zane B.
doi: 10.1038/s41593-023-01508-zpmid: 37990115
Neuroscientists have long believed that hunger increases activity in agouti-related peptide (AgRP) neurons to regulate feeding-related behaviors and metabolism, but a new study shows that the story is much more complicated. Sayar-Atasoy and colleagues show that the time of day uncouples activity in AgRP neurons from hunger and demonstrate how daily feeding patterns influence future AgRP neuron activity.
Updating the striatal–pallidal wiring diagramFang, Lisa Z.; Creed, Meaghan C.
doi: 10.1038/s41593-023-01518-xpmid: 38057614
The striatal and pallidal complexes are basal ganglia structures that orchestrate learning and execution of flexible behavior. Models of how the basal ganglia subserve these functions have evolved considerably, and the advent of optogenetic and molecular tools has shed light on the heterogeneity of subcircuits within these pathways. However, a synthesis of how molecularly diverse neurons integrate into existing models of basal ganglia function is lacking. Here, we provide an overview of the neurochemical and molecular diversity of striatal and pallidal neurons and synthesize recent circuit connectivity studies in rodents that takes this diversity into account. We also highlight anatomical organizational principles that distinguish the dorsal and ventral basal ganglia pathways in rodents. Future work integrating the molecular and anatomical properties of striatal and pallidal subpopulations may resolve controversies regarding basal ganglia network function.