Pathology International

Matsumoto, Noboru; Ishihara, Tokuhiro; Takahashi, Mutsuo; Uchino, Fumiya; Ono, Junichiro; Miwa, Shiro; Kiyomitsu, Yoshinori

doi: 10.1111/j.1440-1827.1976.tb00510.xpmid: 998237

Light and electron microscopic studies of the spleen and liver from a patient with hereditary elliptocytosis have been reported. Characteristic findings are congestion of the cordal space, diminished variation of the erythrocyte shape In the cord, relatively empty sinuses and erythrophagocytosis by the cordal macrophages. The same basic defect of the red cell membrane as has been documented in hereditary spherocytosis might be a possible explanation on the pathogenesis of this rare hemolytic anemia.

Seez, Peter; Mori, Wataru

doi: 10.1111/j.1440-1827.1976.tb00511.xpmid: 998238

Intlmal thickening of the intra‐organ arteries of the major organs have been examined In 253 autopsy cases and, the microscopical findings have been analyzed according to smoking habits. It was found that especially the small arteries of the lung present a significantly higher degree of fibrous intlmal thickening in cigarette smokers.

Tanaka, Toshio; Kobayashi, Kanji; Sho, Tatsuo; Hamazaki, Mikage

doi: 10.1111/j.1440-1827.1976.tb00512.xpmid: 998239

Since our report on Gastleman's lymphoma in 1958, a total of 53 cases by 36 authors have appeared In the Japanese literatures. Among them our first case, whose tumor was found In the pelvic cavity, would be the first patient ever reported in Japan. The outstanding histological features of Castleman's lymphoma consists of variegated morphology of germinal centers due to peculiar capillary proliferation, multicentric germinal centers in a lymph follicle showing a chimerical figure and expansive growth of lymph follicles by compressing interfollicular area. Among these Japanese population, we have noticed the highest age incidence between 10‐19 years, with somewhat female predominance, the most preferential site in the upper part of the body, and, as compared to the other ethnical subjects, more frequent tumor multiplicity and less usual plasma cell type of the tumor. A possible pathogenesis that Castleman's lymphoma could be "a benign lymphoma" in contrast to malignant lymphomas is emphasized from various aspects.

Suda, Koichi; Komatsu, Katsuhiko; Hashimoto, Keisuke

doi: 10.1111/j.1440-1827.1976.tb00513.xpmid: 793291

In autopsy material Isolated islets of Langerhans are frequently encountered in the fatty or the fibrous tissue replacing the pancreatic lobuli. The incidence of isolated islets of Langerhans was 27.0% In the file of a series of randomly selected 100 autopsy cases and increased with advancing age. Fifteen cases of these 27 showed multiple foci and the total number of foci counted 60. Fifty‐two foci (86.7%) were found in the subcapsular area. Clusters of elastic fibers were found in 36 foci (60.0%) Small pancreatic ducts with goblet cell metaplasia were found in 29 foci (48.0%) in the surrounding tissue of the remaining islets of Langerhans. Squamous metaplasia was identified in only 1 focus (0.2%), and luminal dilatation of the duct was found in 4 foci (0.7%) Serial sections showed that the small duct ended without connection to acinar cells. "The Isolated islets of Langerhans" should be the result of the atrophy of pancreatic lobuli subsequent to disappearance of acinar cells.

Miyasaki, Kichihei; Murao, Shinichi

doi: 10.1111/j.1440-1827.1976.tb00514.xpmid: 998240

Foam cells in the spleen, bone marrow, liver and lymph nodes were examined on the 73 reliably recorded and sampled leukemia autopsy cases encountered at Kobe University from 1958 to 1972. Although the substances stored in the foam cells were biochemically unknown, the foam cells In leukemia could be morphologically classified into two types: The one was identified with the Gaucher type, but the other was not identified with the sea‐blue type and might be considered as to be the transitional type described in another report. Foam cells could be found in the spleen of 6 out of 12 cases of chronic myeloid leukemia, one out of 2 cases of chronic lymphatic leukemia, one out of 7 cases of leukemic lymphosarcoma, one out of 9 cases of acute lymphatic leukemia, and none in 3 cases of monocytic leukemia. In acute myeloid leukemia, the incidence of foam cells in the spleen was 47.5% in 40 cases, and acquired lipidoses were more frequently seen in cases under 19 years of age, in male cases, in cases with an enlarged spleen over 400 g, and in cases of over 4 months’duration.

Tanaka, Mitsugu; Kosakai, Mamoru; Inomata, Izuru; Takaki, Keizo; Ishikawa, Eisei

doi: 10.1111/j.1440-1827.1976.tb00515.xpmid: 11635

Inorder to gain a foothold in clarifying the functional significance of fat‐storing cells, an enzyme histochemical study on these cells was carried out. Fat‐storing cells showed no alkaline phosphatase, acid phosphatase or esterase activity but demonstrated a marked γ‐ glutamyl transpeptidase activity suggesting the possibility of its participation in the synthesis of fiber protein. This possibility was further heightened by its remarkable activity noted at the site of progressive fibrosis. Fat‐storing cells under a normal condition partake in the formation of fibers supporting the sinusoidal wall, and under an abnormal condition gradually change their shape with loss of fat droplets and then transform into flbroblast‐like cells closely related to the progress of fibrosis.

Hirano, Tom

doi: 10.1111/j.1440-1827.1976.tb00516.xpmid: 998241

The response of the adrenal cortex In weanling Spontaneously Hypertensive Rats (SHR, OKAMOTO and AOKI) and Wistar‐Kyoto Rats (WKR) when given 1% NaCl In drinking water was studied histochemically and electron microscopically. The development of hypertension was accelerated in SHR given 1% NaCl in drinking water. The thickness of the zona glomerulosa In WKR receiving 1% NaCl in drinking water remarkably diminished following the course of experiment and lipid droplets In the zona glomerulosa decreased gradually. The zona glomerulosa cells revealed shrinkage of the cells and a decreased number of mitochondrial crlstae were observed at three weeks of experiment. The remaining tubular crlstae of mitochondria possessed a milled outline. Golgi apparatus became small and fragmental. Membrane ‐bounded dense bodies were prominent in the peripheral portion of the cell and around Golgl apparatus. In SHR given 1% NaCl in drinking water, the width of the zona glomerulosa less diminished. A marked decrease in number and size of lipid droplets was seen. However, there was no distinct alteration of cytoplasmic organelles. These morphological changes were discussed from the standpoint of functional state In the zona glomerulosa with relation to the development of hypertension in SHR.

Kaneko, Hiroshi; Murohashi, Takeshi; Katano, Akira; Hōjō, Haruto; Ishikawa, Shinobu

doi: 10.1111/j.1440-1827.1976.tb00517.xpmid: 998242

A case of cardiac myxoma associated with renal angioflbrolipomas, renal medullary flbromas, thyroid adenoma and jejunal polyp was presented. So far as we know, the combined form of cardiac myxoma and renal hamartoma has not been hitherto reported. The combination of these various complications may suggest the relationships of tuberous sclerosis, Cowden disease, lymphangiomatosis among others. Besides it is noteworthy that the three of them, i.e. cardiac myxoma, renal angioflbrolipomas and thyroid adenoma, presented considerable atypism at the same time. As to the histogenesis of cardiac myxoma, this case may be in accord with the hamartoma theory.

Sonobe, Hiroshi; Taguchi, Kohji; Ogawa, Katuo; Yoshioka, Tamotsu

doi: 10.1111/j.1440-1827.1976.tb00518.xpmid: 1033657

A 50‐year‐old Japanese female with choriocarcinoma showed three unusual features: the primary tumor developed in the vagina ectopically without uterine lesion; the first symptoms of atypical vaginal bleeding and coughing occurred 23 years after the last pregnancy; and the tumor appeared during postmenopause. The possible mechanisms for the ectopic location and latency are discussed.

Tanaka, Toshio; Komatsubara, Shokichi; Miyoshi, Isao; Hieaki, Shunkichi; Tada, Shinya; Kubonishi, Ichiro; Hujii, Masashi; Sezaki, Tatsuo

doi: 10.1111/j.1440-1827.1976.tb00519.xpmid: 998243

Non‐African Burkitt's lymphoma is presented in a 29‐year‐old, unmarried woman, who developed tumors in both breasts and ovaries, ascites and pleural effusion. Assessment of B cells in the tumor cells, derived from ascites, pleural effusion and tumor tissue is 90%, surface IgM being consisted of 86%, in an average. Histologically, the tumor tissue demonstrates prominent, so‐called starry‐sky effect, and cytologically, tumor cells are poorly‐differentiated lymphocytoid ceUs in their features.