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Wang, Z. Jane; Renata, Hans; Peck, Nicole E.; Farwell, Christopher C.; Coelho, Pedro S.; Arnold, Frances H.
doi: 10.1002/anie.201404337pmid: N/A
Just‐Baringo, Xavier; Albericio, Fernando; Álvarez, Mercedes
doi: 10.1002/anie.201307288pmid: 24861213
The recent development of thiopeptide analogues of antibiotics has allowed some of the limitations inherent to these naturally occurring substances to be overcome. Chemical synthesis, semisynthetic derivatization, and engineering of the biosynthetic pathway have independently led to complementary modifications of various thiopeptides. Some of the new substances have displayed improved profiles, not only as antibiotics, but also as antiplasmodial and anticancer drugs. The design of novel molecules based on the thiopeptide scaffold appears to be the only strategy to exploit the high potential they have shown in vitro. Herein we present the most relevant achievements in the production of thiopeptide analogues and also discuss the way the different approaches might be combined in a multidisciplinary strategy to produce more sophisticated structures.
Dinh, Cao‐Thang; Yen, Hoang; Kleitz, Freddy; Do, Trong‐On
doi: 10.1002/anie.201400966pmid: 24737715
An Au/TiO2 nanostructure was constructed to obtain a highly efficient visible‐light‐driven photocatalyst. The design was based on a three‐dimensional ordered assembly of thin‐shell Au/TiO2 hollow nanospheres (Au/TiO2‐3 DHNSs). The designed photocatalysts exhibit not only a very high surface area but also photonic behavior and multiple light scattering, which significantly enhances visible‐light absorption. Thus Au/TiO2‐3 DHNSs exhibit a visible‐light‐driven photocatalytic activity that is several times higher than conventional Au/TiO2 nanopowders.
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