Nature Cell Biology

doi: 10.1038/ncb1109-1273bpmid: 19884879

On the eve of budget decisions, the scale of cuts to basic research funding remains ill-defined.

doi: 10.1038/ncb1109-1273apmid: 19884880

Reference datasets should be accessible independently of scientific papers in a citable form, allowing attribution.

Schekman, Randy

doi: 10.1038/ncb1109-1274pmid: 19884881

Malumbres, Marcos; Harlow, Edward; Hunt, Tim; Hunter, Tony; Lahti, Jill M.; Manning, Gerard; Morgan, David O.; Tsai, Li-Huei; Wolgemuth, Debra J.

doi: 10.1038/ncb1109-1275pmid: 19884882

Kaeberlein, Matt

doi: 10.1038/ncb1109-1277pmid: 19884883

Identifying therapies to slow down ageing and delay age-associated diseases is a primary goal of ageing-related research. Resveratrol and rapamycin were first found to promote longevity in yeast, and their effects were then extended to several organisms. Spermidine is a new longevity drug that can increase life span in yeast, nematodes and flies, possibly through an effect on chromatin-mediated regulation of gene expression.

Fischle, Wolfgang

doi: 10.1038/ncb1109-1279pmid: 19884884

The tumour suppressor Tip60 is a histone acetyltransferase implicated in transcriptional control and DNA double-strand break repair. Tip60 binds to the heterochromatic histone mark H3K9me3, triggering acetylation and activation of DNA double-strand break repair factors.

Matise, Lauren A.; Pickup, Michael W.; Moses, Harold L.

doi: 10.1038/ncb1109-1281pmid: 19838176

Intravital imaging demonstrates that TGF-β signalling regulates the mode of cancer cell motility. Cells with active TGF-β signalling migrate as single cells and are capable of hematogenous and lymphatic spread, whereas cells lacking TGF-β signalling invade lymphatics collectively.

Bot, Nathalie Le; Grisendi, Silvia; Rosenthal, Christina Karlsson; Swaminathan, Sowmya

doi: 10.1038/ncb1109-1285pmid: N/A

Giampieri, Silvia; Manning, Cerys; Hooper, Steven; Jones, Louise; Hill, Caroline S.; Sahai, Erik

doi: 10.1038/ncb1973pmid: 19838175

In vivo imaging of mammary carcinoma cells reveals that activation of a TGFβ-induced transcriptional response induces the motility of individual cells, allowing them to spread through the blood stream. In the absence of TGFβ, cells migrate as groups and can only metastasize through the lymphatic system.

Gumireddy, Kiranmai; Li, Anping; Gimotty, Phyllis A.; Klein-Szanto, Andres J.; Showe, Louise C.; Katsaros, Dionyssios; Coukos, George; Zhang, Lin; Huang, Qihong

doi: 10.1038/ncb1974pmid: 19801974

A screen for suppressors of breast to lung metastasis leads to the identification of KLF17 (Krüppel-like transcription factor 17), which is shown to be downregulated in breast cancer biopsies. KLF17 inhibits epithelial–mesenchymal transition and invasion by inhibiting the transcription of the metastasis factor Id1.