Worum, Hilde; Lillekroken, Daniela; Ahlsen, Birgitte; Roaldsen, Kirsti; Bergland, Astrid
doi: 10.1186/s12877-019-1309-6pmid: 31638912
Ruan, Ye; Guo, Yanfei; Kowal, Paul; Lu, Ye; Liu, Chazhen; Sun, Shuangyuan; Huang, Zhezhou; Zheng, Yang; Wang, Wenjing; Li, Gan; Shi, Yan; Wu, Fan
doi: 10.1186/s12877-019-1342-5pmid: 31796000
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Anemia and frailty contribute to poor health outcomes in older adults; however, most current research in lower income countries has concentrated on anemia or frailty alone rather than in combination. The aim of the present study was to investigate the association between anemia and frailty in community-dwelling adults aged 50 years and older in China.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>The study population was sourced from the 2007/10 SAGE China Wave 1. Anemia was defined as hemoglobin less than 13 g/dL for men and less than 12 g/dL for women. A Frailty Index (FI) was compiled to assess frailty. The association between anemia and frailty was evaluated using a 2-level hierarchical logistic model.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>The prevalence of anemia was 31.0% (<jats:italic>95%CI</jats:italic>: 28.4, 33.8%) and frailty 14.7% (<jats:italic>95%CI</jats:italic>: 13.5, 16.0%). In the univariate regression model, presence of anemia was significantly associated with frailty (OR = 1.62, <jats:italic>95% CI</jats:italic>: 1.39, 1.90) and the effect remained consistent after adjusting for various potential confounding factors including age, gender, residence, education, household wealth, fruit and vegetable intake, tobacco use, alcohol comsumption and physical activity (adjusted OR = 1.31, <jats:italic>95% CI</jats:italic>:1.09, 1.57). Each 1 g/dL increase in hemoglobin concentration was associated with 4% decrease in the odds of frailty after adjusting for several confounding variables (adjusted OR = 0.96, <jats:italic>95% CI</jats:italic>: 0.93, 0.99).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Anemia and low hemoglobin concentrations were significantly associated with frailty. Therefore, health care professionals caring for older adults should increase screening, assessment of causes and treatment of anemia as one method of avoiding, delaying or even reversing frailty.</jats:p> </jats:sec>
Heeren, Pieter; Devriendt, Els; Fieuws, Steffen; Wellens, Nathalie; Deschodt, Mieke; Flamaing, Johan; Sabbe, Marc; Milisen, Koen
doi: 10.1186/s12877-019-1233-9pmid: 31390994
Boully, Clémence; Vidal, Jean-Sébastien; Guibert, Etienne; Ghazali, Fanny; Pesce, Alain; Beauplet, Bérengère; Roger, Jean-Dominique; Carrière, Isabelle; Timbely, Boubacar; Idiri, Houria; Constensoux, Jean-Pierre; Durocher, Anne-Marie; Dubail, Delphine; Fargier, Marc; Jeandel, Claude; Berrut, Gilles; Hanon, Olivier
Wang, Yun; Zhang, Qiuli; Spatz, Erica; Gao, Yan; Eckenrode, Sheila; Johnson, Florence; Ho, Shih-Yieh; Hu, Shuang; Xing, Chao; Krumholz, Harlan
doi: 10.1186/s12877-019-1117-zpmid: 30975076
Smithson, Alex; Ramos, Javier; Niño, Esther; Culla, Alex; Pertierra, Ubaldo; Friscia, Michele; Bastida, Maria Teresa
doi: 10.1186/s12877-019-1360-3pmid: 31783801
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Urinary tract infections (UTI) are among the most frequent bacterial infections in older adults. The aim of the study was to analyse the existence of differences in clinical features, microbiological data and risk of infection by multidrug-resistant organisms (MDRO) between older and non-older men with febrile UTI (FUTI).</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>This was an ambispective observational study involving older males with a FUTI attended in the Emergency Department. Variables collected included age, comorbidity, diagnostic of healthcare-associated (HCA)-FUTI, clinical manifestations, hospitalization, mortality, and microbiological data.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Five hundred fifty-two males with a FUTI, 329 (59.6%) of whom were older adults, were included. Older males had a higher frequency of HCA-FUTI (<jats:italic>p</jats:italic> < 0.001), increased Charlson scores (<jats:italic>p</jats:italic> < 0.001), had received previous antimicrobial treatment more frequently (<jats:italic>p</jats:italic> < 0.001) and had less lower urinary tract symptoms (<jats:italic>p</jats:italic> < 0.001). Older patients showed a lower frequency of FUTI caused by <jats:italic>E. coli</jats:italic> (<jats:italic>p</jats:italic> < 0.001) and a higher rate of those due to <jats:italic>Enterobacter spp.</jats:italic> (<jats:italic>p</jats:italic> = 0.003) and <jats:italic>P. aeruginosa</jats:italic> (<jats:italic>p</jats:italic> = 0.033). Resistance rates to cefuroxime (<jats:italic>p</jats:italic> = 0.038), gentamicin (<jats:italic>p</jats:italic> = 0.043), and fluoroquinolones (<jats:italic>p</jats:italic> < 0.001<jats:italic>)</jats:italic> in <jats:italic>E. coli</jats:italic> isolates and the prevalence of extended-spectrum beta-lactamase and AmpC producing <jats:italic>E. coli</jats:italic> and <jats:italic>Klebsiella spp.</jats:italic> strains (<jats:italic>p</jats:italic> = 0.041) and MDRO (<jats:italic>p</jats:italic> < 0.001) were increased in older males. Inadequate empirical antimicrobial treatment (<jats:italic>p</jats:italic> = 0.004), frequency of hospitalization (<jats:italic>p</jats:italic> < 0.001), and all cause in-hospital mortality (<jats:italic>p</jats:italic> = 0.007) were higher among older patients. In the multivariate analysis, being admitted from an long term care facility (OR 2.4; 95% CI: 1.06–5.9), having a urinary tract abnormality (OR 2.2; 95% CI: 1.2–3.8) and previous antimicrobial treatment (OR 3.2; 95% CI: 1.9–5.4) were associated to FUTI caused by MDRO.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Older male adults with a FUTI have different clinical characteristics, present specific microbiological features, and antimicrobial resistance rates. In the multivariate analysis being an older male was not associated with an increased risk of FUTI caused by MDRO.</jats:p> </jats:sec>
Buch, Assaf; Eldor, Roy; Kis, Ofer; Keinan-Boker, Lital; Dunsky, Ayelet; Rubin, Amir; Lopez, Adar; Sofer, Yael; Osher, Etty; Marcus, Yonit; Stern, Naftali
doi: 10.1186/s12877-019-1219-7pmid: 31438863
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doi: 10.1186/s12877-019-1215-ypmid: 31370798