The novel bimetallic MOF, ZnCu-MOF-74, has been evaluated for the remediation of tetracycline-contaminated water. ZnCu-MOF-74 was obtained at room temperature, avoiding high pressure and temperature. ZnCu-MOF-74 exhibited chemical stability in the 4–8 pH range. The adsorption result analysis was described using the Elovich kinetic model and the Langmuir adsorption isotherm, suggesting a physicochemical process. The maximum adsorption capacity was estimated at 775.66 mg g−1. The pH of the solution and the presence of ions such as NO3−, SO42−, Na+, Mg2+, Cl−, and Ca2+ had no influence on the removal of tetracycline. In addition, π-interactions and metal complexation were proposed as possible adsorption mechanisms through FT-IR and XPS. ZnCu-MOF-74 showed outstanding cyclability performance, preserving its adsorption capacity after 4 adsorption–desorption cycles, besides exhibiting chemical stability, proving the benefits of applying ZnCu-MOF-74 in the water treatment process.

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Ru(ii)–arene azole complexes as anti-amyloid-β agents

Hacker, Ryan M.; Grimard, Daniela M.; Morgan, Katie A.; Saleh, Eaman; Wrublik, Morgan M.; Meiss, Cade J.; Kant, Caitlyn C.; Jones, Marjorie A.; Brennessel, William W.; Webb, Michael I.

2024 Dalton Transactions

doi: 10.1039/d4dt01740dpmid: 39093049

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Synthesis and reduction of [(C5H4SiMe3)2Ln(μ-OR)]2 (Ln = La, Ce) complexes: structural effects of bridging alkoxides

Brown, Adrian N.; Kelleher, Jack N.; Brown, Alexander M.; Saghy, Peter; Bohl, Joshua J.; Robinson, Jerome R.; Huh, Daniel N.

2024 Dalton Transactions

doi: 10.1039/d4dt02137apmid: 39188244

Alcoholysis of Cp′3Ln (Ln = La, Ce; Cp′ = C5H4SiMe3) generate high-yielding (72–97%) bimetallic LnIII complexes of [Cp′2Ln(μ-OR)]2 [R = Et, iPr, or C6H4-4-tBu]. Single-crystal X-ray diffraction of these complexes reveal unexpected decreases in Ln⋯Ln distances, increasing Cpcent–Ln–Cpcent angles, and increasing intermolecular C⋯C contacts with bulkier bridging alkoxides, in line with structural control driven by significant dispersion forces. 1H NMR spectroscopy of [Cp′2Ce(μ-OEt)]2 and [Cp′2Ce(μ-OiPr)]2 revealed significantly upfield resonances assigned as methylene and methine moieties of −43.74 and −70.85 ppm, respectively. 2D 1H DOSY NMR experiments of [Cp′2Ce(μ-OiPr)]2 in C6D6 supported a dimeric structure in solution, including in the presence of a Lewis base (i.e., THF). Reduction of [Cp′2La(μ-OiPr)]2 using KC8 in the presence of 2.2.2-cryptand at −78 °C generated a purple solution and X-band EPR spectroscopy revealed an eight-line hyperfine pattern indicative of a LaII species.

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Zeitschrift fur Anorganische und Allgemeine Chemie Inorganic Chemistry Frontiers Comments on Inorganic Chemistry Inorganics Reviews in Inorganic Chemistry

With the recent clinical success of anti-amyloid-β (Aβ) monoclonal antibodies, there is a renewed interest in agents which target the Aβ peptide of Alzheimer's disease (AD). Metal complexes are particularly well-suited for this development, given their structural versatility and ability to form stabile interactions with soluble Aβ. In this report, a small series of ruthenium–arene complexes were evaluated for their respective ability to modulate both the aggregation and cytotoxicity of Aβ. First, the stability of the complexes was evaluated in a variety of aqueous media where the complexes demonstrated exceptional stability. Next, the ability to coordinate and modulate the Aβ peptide was evaluated using several spectroscopic methods, including thioflavin T (ThT) fluorescence, dynamic light scattering (DLS), and transmission electron microscopy (TEM). Overall, the complex RuBO consistently gave the greatest inhibitory action towards Aβ aggregation, which correlated with its ability to coordinate to Aβ in solution. Furthermore, RuBO also had the lowest affinity for serum albumin, which is a key consideration for a neurotherapeutic, as this protein does not cross the blood brain barrier. Lastly, RuBO also displayed promising neuroprotective properties, as it had the greatest inhibition of Aβ-inducted cytotoxicity.