Dalton Transactions

doi: 10.1039/d5dt90023apmid: N/A

doi: 10.1039/d5dt90024gpmid: N/A

doi: 10.1039/d5dt90025epmid: N/A

Li, Suying; Chen, Yan; Feng, Shuaiqi; Liu, Zhifang; Gan, Linling; Wang, Qingpeng

doi: 10.1039/d4dt03162hpmid: 39804164

Pt(iv) complexes as prodrugs of Pt(ii) drugs exhibit numerous advantages such as enhanced stability, reduced toxicity, increased oral bioavailability, and efficacy in overcoming the drug resistance of Pt(ii) compounds, which underscore their significant potential in the advancement of novel Pt anticancer agents. Furthermore, protective autophagy is pivotal in sustaining tumor cell homeostasis and modulating the tumor microenvironment (TME), thereby representing a critical target for the development of antitumor drugs. Specific inhibition or activation of autophagy during chemotherapy would break the internal homeostasis in the TME and increase antitumor activities. Consequently, developing novel Pt(iv) antitumor agents with autophagy-targeting capabilities by incorporating autophagy-regulating moieties into the Pt(iv) framework has emerged as a hot topic in the discovery of novel Pt drugs. Herein, the research progress in novel Pt(iv) antitumor drugs with autophagy-targeted properties is systematically reviewed based on the literature. The future challenges and perspectives of this fascinating class of conjugates are also discussed, aiming to provide new insights and approaches for the future design and investigation of novel Pt antitumor drugs.

Geppert, Marcel; Müller, Michelle; Linseis, Michael; Winter, Rainer F.

doi: 10.1039/d4dt03304cpmid: 39804203

We present the synthesis, characterization, and photophysical properties of two pyrene-modified (NCN) pincer bismuth complexes, where the pyrenyl residues are either part of the cyclometalating pincer ligand (1) or bound as monodentate ligands to the BiIII ion (2). Both complexes are dually emissive at 77 K. For complex 2, pyrenyl phosphorescence persists at r.t. in degassed CH2Cl2, albeit with reduced intensity. This renders 2 one of only a handful of Bi complexes showing this property.

Wang, Tao; Li, Bin; Zhang, Yu; Xu, Shuting; Wang, Jun; Zheng, Jianwei; Li, Hao; Zhang, Fengjun; Fang, Xiaolong

doi: 10.1039/d4dt03338hpmid: 39817494

A universal and green catalytic system for the hydrogenation of unsaturated aldehydes and ketones into the corresponding alcohols with the C00000000000000000000000000000000111111110000000011111111000000000000000000000000C bonds retained under atmospheric hydrogen pressure in the water phase was realized by N-functionalized amino ligand-stabilized ruthenium complexes (o-PPh2C6H4NHMe)[(CH2NHR)2]RuCl2 (R = H, Me, Et) and (o-PPh2C6H4NMe2)[(CH2NHEt)2]RuCl2 with wide substrate compatibility and excellent functionality tolerance. The structural synergism between o-PPh2C6H4NHMe and (CH2NHEt)2 achieves the enhanced performance, with a positive correlation with the electron density of the amino ligand.

Dhir, Rupy; Shah, Bulle; Singh, Narinder

doi: 10.1039/d5dt90010gpmid: 39791374

Expression of concern for ‘Synthesis and characterization of a novel copper carboxylate complex and a copper complex-coated polyether sulfone membrane for efficient degradation of methylene blue dye under UV irradiation: the single crystal X-ray structure of the copper carboxylate complex’ by Rupy Dhir et al., Dalton Trans., 2024, 53, 9441–9451, https://doi.org/10.1039/D4DT00871E.

Kumar, Subodh; Jain, Suman L.

doi: 10.1039/d4dt90224fpmid: 39812619

Expression of Concern for ‘A nanostarch functionalized ionic liquid containing imidazolium cation and cobalt chelate anion for the synthesis of carbamates from amines and dimethyl carbonate’ by Subodh Kumar and Suman L. Jain, Dalton Trans., 2013, 42, 15214–15218, https://doi.org/10.1039/C3DT52127C.

Verma, Sanny; Le Bras, Jean; Jain, Suman L.; Muzart, Jacques

doi: 10.1039/d4dt90223hpmid: 39820250

Expression of concern for ‘Nanocrystalline starch grafted palladium(ii) complex for the Mizoroki–Heck reaction’ by Sanny Verma et al., Dalton Trans., 2013, 42, 14454–14459, https://doi.org/10.1039/C3DT51685G.

Kumar, Pawan; Chauhan, R. K.; Sain, Bir; Jain, Suman L.

doi: 10.1039/d4dt90225dpmid: 39820624

Expression of Concern for ‘Photo-induced reduction of CO2 using a magnetically separable Ru-CoPc@TiO2@SiO2@Fe3O4 catalyst under visible light irradiation’ by Pawan Kumar et al., Dalton Trans., 2015, 44, 4546–4553, https://doi.org/10.1039/C4DT02461C.