Nature Immunology

doi: 10.1038/s41590-023-01704-wpmid: 38012407

Cancer immunology research is diverse, uses cutting-edge technologies and continues to excite with its constantly evolving contribution to new therapeutic options, and not just for patients with cancer.

Teyton, Luc

doi: 10.1038/s41590-023-01657-0pmid: 37845490

Dempsey, Laurie A.

doi: 10.1038/s41590-023-01701-zpmid: 37996763

Bernard, Nicholas J.

doi: 10.1038/s41590-023-01698-5pmid: 37996762

Visan, Ioana

doi: 10.1038/s41590-023-01702-ypmid: 37996765

Houston, Stephanie

doi: 10.1038/s41590-023-01703-xpmid: 37996764

Odio, Camila D.; Aogo, Rosemary A.; Lowman, Kelsey E.; Katzelnick, Leah C.

doi: 10.1038/s41590-023-01680-1pmid: 38012410

The immune response to dengue virus infection is a well-coordinated balancing act. New research shows that an imbalanced response — driven partially by the productive infection of antigen-presenting cells — is associated with progression to severe disease.

Catz, Sergio D.

doi: 10.1038/s41590-023-01684-xpmid: 37914819

S100A8 and S100A9 are cytosolic alarmins with autocrine functions that facilitate neutrophil recruitment. Rapid, transient gasdermin-D pore formation is now shown to mediate secretion of these proteins in response to E-selectin without driving pyroptosis.

Siniscalco, Emily R.; Craft, Joe

doi: 10.1038/s41590-023-01683-ypmid: 37932458

Regulatory T (Treg) cells maintain the balance between immune protection and pathology. Research has now found that intestinal Treg cells produce IL-27 to restrain TH17 cell-mediated immune responses, effectively restricting autoimmune inflammation and limiting T cell responses to certain gut pathogens.

Naidoo, Kewreshini; Altfeld, Marcus

doi: 10.1038/s41590-023-01679-8pmid: 37919526

Determining the immune crosstalk between macrophages and NK cells in bronchioalveolar lavage fluid during SARS-CoV-2 infection in macaques identifies immunoregulatory properties of NK cells and their implications for viral persistence.