Nature Immunology

Hajishengallis, George; Netea, Mihai G.; Chavakis, Triantafyllos

doi: 10.1038/s41590-023-01595-xpmid: 37620602

Niec, Rachel; Carvalho, Thiago L.; Mucida, Daniel

doi: 10.1038/s41590-023-01546-6pmid: 37524801

The effects of climate change driven by human activity are now part of the daily news cycle, and time is running out for decisive action.

Houston, Stephanie

doi: 10.1038/s41590-023-01615-wpmid: 37604941

Visan, Ioana

doi: 10.1038/s41590-023-01616-9pmid: 37604942

Bernard, Nicholas J.

doi: 10.1038/s41590-023-01617-8pmid: 37604943

Dempsey, Laurie A.

doi: 10.1038/s41590-023-01618-7pmid: 37604944

Hassert, Mariah; Harty, John T.

doi: 10.1038/s41590-023-01594-ypmid: 37580607

Malaria is a vector-borne disease caused by Plasmodium parasites. In an exciting new study, Ganley et al. harness the power of mRNA vaccines to summon tissue-resident memory T cells to battle the parasite as it replicates in the liver.

Sica, Antonio; Lazzeri, Massimo

doi: 10.1038/s41590-023-01592-0pmid: 37580608

The functional heterogeneity of macrophages has ontological and microenvironmental bases, and differentially affects pathology. In pancreatitis, tissue-resident macrophages promote protective fibrosis that favors the maintenance of pancreatic homeostasis. In pancreatic ductal adenocarcinoma, they promote tumor progression by facilitating stromal desmoplasia.

Dash, Barsha; Hogan, Patrick G.

doi: 10.1038/s41590-023-01596-wpmid: 37580606

The first detailed investigation of CD8+ tumor-infiltrating T cell differentiation in the hours after cells enter a tumor has yielded an unexpected twist. Naive T cells veer away from effector fate and enter the path towards exhaustion much earlier than expected.

Vilbois, Stefania; Park, Jaeoh; Ho, Ping-Chih

doi: 10.1038/s41590-023-01598-8pmid: 37620603

A recent study shows how intratumoral glutamine supplementation can improve the function of tumor-infiltrating dendritic cells and enhance the CD8+ T cell anti-tumor response.