Journal of Cardiovascular Risk

Wilcken, David E.L.

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We conclude that the methionine synthase 2756A→G mutation is common, with homozygosity occurring in approximately 4% of white Australians, and that it has an interactive effect with life-time smoking dose to increase the severity of CAD. Smokers who are also GG homozygotes have additionally elevated CAD risk.

Strauer, Bodo E.

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A significantly increased risk of acute complications could only be documented in women undergoing PTCA for stable angina pectoris and not in acute coronary syndrome. Long-term outcome was similar between the two sexes

Sanderson, John E.

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We hypothesize that differences in the frequency of the ACE DD genotype in populations with low mean serum cholesterol concentrations may play some part in determining interethnic differences in CHD mortality rates.

Baker, Julian

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In addition to the abnormal lipid-lipoprotein profile in subjects with CAD, the present data also suggest that while physical activity confers metabolic cardioprotection, a threshold stimulus exists beyond which no further benefits can be gained

Desai, Dushyant K.

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Young black people had higher blood pressure readings than young Indian participants in the absence of metabolic abnormalities and had greater cardiac involvement. Borderline hypertension is not innocuous. Metabolic risk factors for CHD in Indian people are apparent at an early age. This study emphasizes the need for prevention of risk factors leading to CHD at an early age

Keinänen-Kiukaanniemi, Sirkka M.

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We conclude that clusters of metabolic abnormalities associated with insulin resistance are already present in young men, and that the prevalence of these clusters in smokers is sixfold compared with non-smokers.

Njølstad, Inger

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The markedly adverse levels of modifiable risk factors found in individuals whose brothers or sisters developed heart disease offer a potential for prevention in families with heart disease

Harano, Yutaka

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Restenosis following elective and successive PTCA was significantly more frequent in poorly controlled NIDDM compared with moderately or well-controlled NIDDM or non-diabetic subjects. Multivariate analysis also showed the significant correlation between restenosis and glycemic control. These findings indicate that control of diabetes plays an important role in reducing restenosis after PTCA.

Janarthanan, Ramakrishnan Athimoolam

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The level of this protein could be an early molecular marker identifying the stages of increase in LVM mass in patients with cardiac hypertrophy, below 40 years of age. The induction of 182 kDa protein levels in human serum may be an age-dependent phenomenon

Duriez, Patrick

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These data suggest that α-Toch strongly inhibits thrombin-induced endothelin secretion in vitro at least partly through PKC inhibition