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Fu, Qiang; Lu, Zhongqi; Chang, Ying; Jin, Tiefeng; Zhang, Meihua
doi: 10.1002/fsn3.3932pmid: 38628201
A growing number of publications have shown that resveratrol has anticancer effects and has become a hotspot in cancer research. The purpose of this study is to analyze the academic results and research trends in resveratrol within the field of anticancer and to predict the future trends in this field. We conducted a literature search for resveratrol in anticancer research from 2003 to 2022 using the Science Citation Index Expanded of the Web of Science Core Collection. The visualization software was used to perform the bibliometric analysis. A total of 1463 publications from 2003 to 2022 were retrieved. China had the highest number of publications. Taipei Medical University became the research institution with the largest number of publications worldwide. The journals with the highest output and co‐citation frequency were Molecules and Cancer Research. Levenson, Anait S and Jaeger, Walter published the largest number of papers. Jang, MS was the most co‐cited author. Timeline View shows trends and relationship between research topics over time and suggests that the emerging frontier of resveratrol in anticancer may be “resveratrol induces apoptosis.” As more and more evidence shows the important role of resveratrol in anticancer, further research on its mechanisms and target discovery may become a major direction for future research. The bibliometric analysis findings of this study will significantly contribute to scholars' comprehensive understanding of the anticancer effects and mechanisms of action of resveratrol, aiding in delineating research hotspots and frontier directions within this field, thereby providing guidance for future investigations.
Faisal, Zargham; Mazhar, Aimen; Batool, Syeda Ayesha; Akram, Noor; Hassan, Maleeha; Khan, Muhammad Usman; Afzaal, Muhammad; Hassan, Usman Ul; Shah, Yasir Abbas; Desta, Derese Tamiru
doi: 10.1002/fsn3.3933pmid: 38628180
Resveratrol, a natural polyphenol in various plants, has gained significant attention for its potential health‐promoting properties. It has been demonstrated, after reviewing various clinical and in vitro studies, that resveratrol possesses potent antioxidant potential. Resveratrol demonstrates cellular component protection by directly neutralizing free radicals (FRs) and enhancing the expression of natural antioxidant enzymes, thereby mitigating oxidative damage to proteins, lipids, and nucleic acids. Clinical trials have shown promising results, indicating that resveratrol supplementation can enhance antioxidant defenses and reduce oxidative damage markers in various populations. In addition to its antioxidant effects, resveratrol exhibits potent anti‐inflammatory properties. It can modulate key inflammatory pathways, such as nuclear factor‐kappa B (NF‐κB) and mitogen‐activated protein kinases (MAPKs), thereby suppressing the production of pro‐inflammatory cytokines and chemokines. Furthermore, resveratrol's multimodal effects extend beyond its antioxidant and anti‐inflammatory properties. It has been discovered to exert regulatory effects on various cellular processes, including apoptosis, cell cycle progression, angiogenesis, and immunological responses. The primary aim of this review paper is to provide a thorough overview of the current knowledge on resveratrol, including its chemical composition, bioaccessibility, clinical effectiveness, and utilization in nanotechnology to enhance its bioavailability. From future perspectives, revising the administration methods for certain contexts and understanding the underlying systems responsible for resveratrol's effects will require further inquiry. For the highest potential health results, advanced trial‐based research is necessary for combinational nano‐delivery of resveratrol.
Jazinaki, Mostafa Shahraki; Bahari, Hossein; Rashidmayvan, Mohammad; Arabi, Seyyed Mostafa; Rahnama, Iman; Malekahmadi, Mahsa
doi: 10.1002/fsn3.3940pmid: 38628181
Research into the effects of raspberry on blood pressure and lipid profiles is inconclusive. This meta‐analysis was aimed to determine whether raspberry has beneficial effects in clinical practice and to what extent these effects are associated with blood pressure and lipid profiles. A systematic literature search up to September 2023 was completed in PubMed/Medline, Scopus, and Web of Science, to identify eligible RCTs. Heterogeneity tests of the selected trials were performed using the I2 statistic. Random effects models were evaluated based on the heterogeneity tests, and pooled data were determined as weighted mean differences with a 95% confidence interval. Eleven randomized controlled trials (with 13 arms) were eligible for this meta‐analysis. Our findings revealed that Raspberry consumption had no significant effects on the blood pressure and lipid profile markers, including systolic blood pressure (SBP) (WMD, −0.37 mm Hg; 95%CI: −2.19 to 1.44; p = .68), diastolic blood pressure (DBP) (WMD, −2.14 mm Hg; 95%CI: −4.27 to 0.00; p = .05), total cholesterol (TC) (WMD, −6.83 mg/dL; 95%CI: −15.11 to 1.44; p = .10), triglycerides (TG) (WMD, −5.19 mg/dL: 95%CI: −11.76 to 1.37; p = .12), low‐density lipoprotein‐cholesterol (LDL‐C) (WMD, −5.19 mg/dL; 95%CI: −11.58 to 1.18; p = .11), and high‐density lipoprotein‐cholesterol (HDL‐C) (WMD, 0.82 mg/dL; 95%CI: −1.67 to 3.32; p = .51), compared to control groups. Subgroup analysis showed that raspberry consumption significantly decreased total cholesterol and LDL‐C levels in people with elevated TC levels, metabolic syndrome, and andropause symptoms, as well as those older than 35, while the consumption of raspberries led to a significant increase in HDL‐C levels in females, obese, under 35, and healthy individuals. Raspberry can improve lipid profile and blood pressure, but it is important to keep in mind that further research is necessary to fully understand the exact mechanism of action and a definite conclusion in this regard.
Teymoori, Farshad; Norouzzadeh, Mostafa; Farhadnejad, Hossein; Jahromi, Mitra Kazemi; Ahmadirad, Hamid; Saber, Niloufar; Akbarzadeh, Mahdi; Zarkesh, Maryam; Daneshpour, Maryam S.; Mirmiran, Parvin; Vafa, Mohammadreza
doi: 10.1002/fsn3.3957pmid: 38628192
In the current study, we aimed to review the evidence from twin and family‐based studies that have assessed the familial similarity in intakes of energy and macronutrients among various parent–child pairs. The online literature databases, including Web of Science, PubMed, and Scopus, were searched up to December 2022 to find potentially eligible studies. We converted Pearson's, Spearman's, or intra‐class correlation coefficients to z's using Fisher's z transformation to obtain approximate normality and then calculated a mean and standard error (SE) of transformed correlation weighted by the sample sizes in the studies. We reported pooled r and 95% CI as our final results in five groups, including parent–child, mother–daughter, mother–son, father–daughter, and father–son. Twenty‐one eligible studies were included in this meta‐analysis, in which the sample size ranged from 33 and 4310. Our analysis showed that family resemblance in the intake of energy and macronutrients in various parent–offspring pairs was weak to moderate which could be different based on family pairs, nutrients, and studies. The highest similarity in dietary intakes was observed among the mother–daughter pair, which was for carbohydrate and protein intake, respectively. The lowest correlations in dietary intakes were found between mother–son or father–son pairs. Our meta‐analysis suggested that family similarity for intakes of energy and macronutrients was not strong in parent–child pairs. The highest correlation in dietary intake was mostly found in mother–daughter pairs. The weak similarities in dietary intake among parent–child pairs indicate the noticeable effect of the environment outside the family on individuals' dietary choices.
Faisal, Zargham; Irfan, Rushba; Akram, Noor; Manzoor, Hafiz Muhammad Irfan; Aabdi, Mohib Ali; Anwar, Muhammad Junaid; Khawar, Sharjeel; Saif, Asifa; Shah, Yasir Abbas; Afzaal, Muhammad; Desta, Derese Tamiru
doi: 10.1002/fsn3.3959pmid: 38628211
The present lifestyle, dietary patterns, psychological pressure, environmental factors, and the widespread exploitation of processed substances in food production and farming have collectively contributed to a substantial expediting in the development of various health problems. Globally, researchers have been seeking natural pharmaceutical substances with the potential to be employed in treating lifestyle‐related diseases or delaying their onset. Fenugreek seeds have gained significant attention in various fields, including health, nutrition, and cutting‐edge nanotechnology applications, due to their versatile qualities. The current investigation offers a comprehensive discussion of the nutritional composition and therapeutic potential of fenugreek seeds, with an emphasis on their plentiful reservoir of bioactive compounds. This seed demonstrates promising medicinal potential in addressing a wide range of health issues. Significantly, these findings indicate noteworthy properties, such as antidiabetic, antioxidant, anti‐obesity, hypocholesterolemic, anticancer, and cardioprotective effects. Moreover, the components of fenugreek seeds are important in the development of a multitude of foods, which is the reason why they are used extensively in the area of food research. In addition to their nutritional value, their exploration of nanotechnology reveals a promising domain, utilizing the distinctive characteristics of seeds for many purposes, such as nanoparticle synthesis and oil for edible films and nanoemulsions. This review article focuses on a comprehensive analysis of fenugreek seeds, examining their wide‐ranging applications in the fields of health, nutrition, food, and nanotechnology.
Samei, Melika; Dowlatkhahi, Nafiseh; Boozari, Motahareh; Hosseinzadeh, Hossein
doi: 10.1002/fsn3.3972pmid: 38628188
Imagine consuming a daily diet rich in fatty acids to help treat diseases such as hypertension and obesity. This concept presents an attractive paradox. In particular, consuming walnut kernels is beneficial for treating diseases associated with metabolic syndrome (MetS), including type 2 diabetes, cardiovascular disease, dyslipidemia, and obesity. Different parts of the Juglans regia tree (family Juglandaceae), including its leaves, green husks, bark, and septum, have shown promising effects on pathological conditions related to MetS. The therapeutic advantages of consuming walnut kernels for MetS can be attributed to the presence of polyunsaturated fatty acids and polyphenolic compounds such as juglone and ellagic acid. Diets enriched with walnut kernel have a positive impact on MetS complications by reducing diastolic blood pressure, improving blood lipid profiles, lowering fasting blood sugar levels, and increasing insulin sensitivity. The potential cellular mechanisms responsible for these benefits involve activating the cholesterol hemostasis pathway by inhibiting sterol regulatory element‐binding proteins (SREBPs), proprotein convertase subtilisin/kexin type 9 (PCSK9), and cholesteryl ester transfer protein (CETP). Furthermore, other by‐products of walnuts, such as leaves and green husks, have also demonstrated effectiveness in managing MetS. These findings highlight the potential of incorporating walnut‐based products into our diets as a natural approach to combating MetS and its complications.
Ahmadnia, Fatemeh; Alebrahim, Mohammad Taghi; Nabati Souha, Leyli; MacGregor, Dana R.
doi: 10.1002/fsn3.3920pmid: 38628215
By identifying the factors that initiate seed dormancy release, we can reliably predict whether a seed will remain dormant within or exit the seed bank and become a seedling. With regard to annual weed species, assessing which factors efficiently break seed dormancy is critical for estimating the number of weed seeds that will develop into problematic weeds. To better understand dormancy breaking in Redroot pigweed (Amaranthus retroflexus), dormant seeds were treated with cold stratification (4°C for 30 days), application of gibberellic acid (at 500, 1000, 1500, and 2000 parts per million), ultrasound (for 10, 20, 30, and 40 min), soaking in hot water (90°C for 3, 5, 7, and 10 min), and 98% sulfuric acid (for 1, 2, and 3 min). The results showed that Redroot pigweed seed dormancy was effectively broken by cold stratification, gibberellic acid, and ultrasound. Short treatments with hot water had minimal effect while longer times or treatment with sulfuric acid stopped seed germination. In addition to germination percentage, germination rate, plumule length, radicle length, seedling length, seedling dry weight, and seed vigor index were also measured; similarly, application of gibberellic acid had the most significant effect on these parameters. The results of this study add to our knowledge of what processes effectively or ineffectively break Redroot pigweed seed dormancy and promote growth.
Hung, Chien‐Min; Chu, Wen‐Cheng; Huang, Wen‐Yen; Lee, Pei‐Jung; Kuo, Wen‐Chih; Hou, Cheng‐Yu; Yang, Chia‐Chun; Yang, Ai‐Jen; Wu, Wei‐Kai; Kuo, Ming‐Liang; Wu, Ming‐Shiang; Chen, Wan‐Jiun
doi: 10.1002/fsn3.3921pmid: 38628176
A safety evaluation was performed of Symbiota®, which is made by a proprietary anaerobic fermentation process of soybean with multistrains of probiotics and a yeast. The battery of genotoxicity studies showed that Symbiota® has no genotoxic effects. Safety and tolerability were further assessed by acute or repeated dose 28‐ and 90‐day rodent studies, and no alterations in clinical observations, ophthalmological examination, blood chemistry, urinalysis, or hematology were observed between the control group and the different dosing groups (1.5, 5, and 15 mL/kg/day). There were no adverse effects on specific tissues or organs in terms of weight and histopathology. Importantly, the Symbiota® treatment did not perturb hormones and other endocrine‐related endpoints. Of note, the No‐Observed‐Adverse‐Effect‐Level was determined to be 15 mL/kg/day in rats. Moreover, a randomized, double‐blind, placebo‐controlled clinical trial was recently conducted with healthy volunteers who consumed 8 mL/day of placebo or Symbiota® for 8 weeks. Only mild adverse events were reported in both groups, and the blood chemistry and blood cell profiles were also similar between the two groups. In summary, this study concluded that the oral consumption of Symbiota® at 8 mL/day by the general population does not pose any human health concerns.
Jenfa, Mary Damilola; Adelusi, Oluwasola Abayomi; Aderinoye, Aderonke; Coker, Oluwafemi Jeremiah; Martins, Itohan Ebunoluwa; Obadina, Olusegun Adewale
doi: 10.1002/fsn3.3922pmid: 38628183
Sorghum and orange‐fleshed sweet potato (OFSP) flours were blended to produce composite flours at eight different ratios of 90:10, 80:20, 70:30, 60:40, 50:50, 40:60, 30:70, and 20:80, respectively, whereas 100% sorghumflour was used as control. The physicochemical compositions, nutritional and functional properties, as well as color attributes of the composite flour blends were evaluated. The acquired data were analyzed using ANOVA, and the means were separated using the Duncan multiple range test. Significant differences (p < .05) were observed in the physicochemical and nutritional properties of the flour blends. The protein levels in the composite flour decreased as the proportion of OFSP flour increased. However, the levels of vitamins, particularly vitamins A and C contents of the composite flours increased with higher proportions of OFSP, ranging from 0.27 and 1.74 mg/100 g in sample S100 to 2.13 and 2.12 mg/100 g in sample S20O80, respectively. In contrast, an increase in the percentage of OFSP flour resulted in a decrease in the contents of vitamin B‐complex, particularly vitamins B2 and B6. These values decreased slightly from 0.19 and 1.98 mg/100 g in sample S100 to 0.16 and 0.03 mg/100 g in sample S20O80, respectively. Furthermore, as the proportion of OFSP flour increased, there was a reduction in the calcium levels from 17.39 mg/100 g in the 100% sorghum sample to 13.52 mg/100 g in the S20O80 sample. However, no particular trend was observed in, magnesium, iron, and phosphorus levels. Sample S50O50 had the highest percentage of essential and conditional amino acids, except for cysteine, valine, and phenylalanine. The findings also revealed significant variations (p < .05) in the composite flour samples' functional properties and color measurements. Substituting sorghum with OFSP in sorghum‐based food products would significantly increase their vitamin A content.
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