This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract The author publishes in monographic form his clinical and experimental observations on the secretion and flow of bile, citing the literature as it bears on the subject under discussion. He finds that pituitary in man has, at the same time, a cholekinetic and an anticholeretic action, and has considerable diagnostic significance in disease of the biliary passages. He records his studies on bile sediment after the administration of "decholin" and attaches diagnostic significance to his results. He reviews his results following the use of various therapeutic agents on diseases of the biliary passages, citing numerous cases. Every one interested in the study and diagnosis of disease of the biliary ducts should have a copy of this monograph at hand.