TY - JOUR
AU - 
AB - Downloaded from genesdev.cshlp.org on October 24, 2021 - Published by Cold Spring Harbor Laboratory Press REVIEW FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease 1,3 2 David M. Ornitz and Pierre J. Marie Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri 63110, USA; Laboratory of Osteoblast Biology and Pathology, INSERM U349 affiliated CNRS, Hopital Lariboisiere, Paris cedex 10, France Over the last decade the identification of mutations in ized type II collagen-expressing chondrocytes and more the receptors for fibroblast growth factors (FGFs) has de- peripherally localized type I collagen-expressing peri- fined essential roles for FGF signaling in both endochon- chondrial cells (Kosher et al. 1986). At this stage, chon- dral and intramembranous bone development. FGF sig- drocytes begin to elaborate a specialized extracellular naling pathways are essential for the earliest stages of matrix containing type II collagen. Midway between the limb development and throughout skeletal develop- ends of this elongated cartilaginous template, chondro- ment. In this review, we examine the role of FGF signal- cytes exit the cell cycle, hypertrophy, and begin to syn- ing in bone development and in human genetic diseases thesize type X collagen in place 
TI - FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
JF - Genes & Development
DO - 10.1101/gad.990702
DA - 2002-06-15
UR - https://www.deepdyve.com/lp/unpaywall/fgf-signaling-pathways-in-endochondral-and-intramembranous-bone-00O37jokbl
DP - DeepDyve
ER -