TY - JOUR
AU - Aldrich, R W
AB - The potassium channels encoded by the Drosophila Shaker gene activate and inactivate rapidly when the membrane potential becomes more positive. Site-directed mutagenesis and single-channel patch-clamp recording were used to explore the molecular transitions that underlie inactivation in Shaker potassium channels expressed in Xenopus oocytes. A region near the amino terminus with an important role in inactivation has now been identified. The results suggest a model where this region forms a cytoplasmic domain that interacts with the open channel to cause inactivation.
TI - Biophysical and molecular mechanisms of Shaker potassium channel inactivation.
JF - Science (New York, N.Y.)
DO - 10.1126/science.2122519
DA - 1990-12-06
UR - https://www.deepdyve.com/lp/pubmed/biophysical-and-molecular-mechanisms-of-shaker-potassium-channel-01p06hMccW
SP - 533
EP - 8
VL - 250
IS - 4980
DP - DeepDyve
ER -