TY - JOUR
AU - Sinclair, David A.
AB - 


Sirtuins are a critical component of evolutionarily conserved longevity pathways. Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases that promote longevity and healthy ageing.


Sirtuin-activating compounds (STACs) bind to and allosterically modulate the affinity of SIRT1 for NAD+ and protein substrates, resulting in increased activity.


Increasing NAD+ levels through various strategies can enhance the activity of all sirtuins and improve metabolic function and increase longevity.


Sirtuin overexpression and treatment with naturally occurring and synthetic STACs improves metabolic function and increases longevity in mice.


More than 50 clinical trials are currently evaluating the safety and physiological activity of naturally occurring and synthetic STACs for treating human disease.



TI - Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
JF - Nature Reviews Molecular Cell Biology
DO - 10.1038/nrm.2016.93
DA - 2016-08-24
UR - https://www.deepdyve.com/lp/springer-journals/slowing-ageing-by-design-the-rise-of-nad-and-sirtuin-activating-024R2z3SBO
SP - 679
EP - 690
VL - 17
IS - 11
DP - DeepDyve
ER -