TY - JOUR
AU - Korswagen, Hendrik C.
AB - Wnt proteins are lipid modified glycoproteins that play a central role in development, adult tissue homeostasis and disease. Secretion of Wnt proteins is mediated by the Wnt-binding protein Wntless (Wls), which transports Wnt from the Golgi network to the cell surface for release. It has recently been shown that recycling of Wls through a retromer-dependent endosome-to-Golgi trafficking pathway is required for efficient Wnt secretion, but the mechanism of this retrograde transport pathway is poorly understood. Here, we report that Wls recycling is mediated through a novel retromer pathway that is independent of the retromer sorting nexins SNX1-SNX2 and SNX5-SNX6. We found that the unrelated sorting nexin, SNX3, has an evolutionarily conserved function in Wls recycling and Wnt secretion and show that SNX3 interacts directly with the cargo-selective sub-complex of the retromer to sort Wls into a morphologically distinct retrieval pathway. These results demonstrate that SNX3 is part of an alternative retromer pathway that functionally separates the retrograde transport of Wls from other retromer cargo.
TI - A SNX3-dependent Retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion
JF - Nature Cell Biology
DO - 10.1038/ncb2281
DA - 2011-07-03
UR - https://www.deepdyve.com/lp/pubmed-central/a-snx3-dependent-retromer-pathway-mediates-retrograde-transport-of-the-06ayodV5Eg
SP - 914
EP - 923
VL - 13
IS - 8
DP - DeepDyve
ER -