TY - JOUR
AU - Stefan, Schulte-Merker
AB -  Introduction In placental mammals (eutherians), there exist three paralogous genes of the vascular endothelial growth factor (VEGF) receptor family, namely FLT1 (also named VEGFR1), KDR (also named FLK1 and VEGFR2), and FLT4 (also named VEGFR3). Recent analysis of the VEGF receptor repertoire in basally diverging vertebrates has identified a fourth representative of this gene family, which was secondarily lost within the eutherian lineage, but is still present in marsupials and platypus (monotremata). Because this fourth member was initially described as an orthologue of the human KDR gene in zebrafish, confusion has arisen regarding the evolutionary relationships of vertebrate VEGF receptors. Here, we revise the nomenclature of zebrafish VEGF receptors and name the fourth vertebrate VEGF receptor gene kdr-like . The members of the VEGF family of ligands, among them VEGF-A, VEGF-B, and VEGF-C, mediate cellular responses by binding their cognate receptors. The receptors, which belong to the type III receptor tyrosine kinase family, are single-pass transmembrane proteins containing seven extracellular immunoglobulin domains and a split intracellular tyrosine kinase domain. In human, mouse, and other mammals, three VEGF receptors have been identified, namely FLT1 (also named VEGFR1), KDR (also named FLK1 and VEGFR2), and FLT4 (also named VEGFR3). Since 
TI - Zebrafish VEGF Receptors: A Guideline to Nomenclature
JF - PLoS Genetics
DO - 10.1371/journal.pgen.1000064
DA - 2008-05-30
UR - https://www.deepdyve.com/lp/public-library-of-science-plos-journal/zebrafish-vegf-receptors-a-guideline-to-nomenclature-0JSFj2TjtO
VL - 4
IS - 5
DP - DeepDyve
ER -