TY - JOUR
AU1 - Gruber, Andreas R.
AU2 - Fallmann, Jrg
AU3 - Kratochvill, Franz
AU4 - Kovarik, Pavel
AU5 - Hofacker, Ivo L.
AB - AREsite is an online resource for the detailed investigation of AU-rich elements (ARE) in vertebrate mRNA 3-untranslated regions (UTRs). AREs are one of the most prominent cis-acting regulatory elements found in 3-UTRs of mRNAs. Various ARE-binding proteins that possess RNA stabilizing or destabilizing functions are recruited by sequence-specific motifs. Recent findings suggest an essential role of the structural mRNA context in which these sequence motifs are embedded. AREsite is the first database that allows to quantify the structuredness of ARE motif sites in terms of opening energies and accessibility probabilities. Moreover, we also provide a detailed phylogenetic analysis of ARE motifs and incorporate information about experimentally validated targets of the ARE-binding proteins TTP, HuR and Auf1. The database is publicly available at: http://rna.tbi.univie.ac.at/AREsite.
TI - AREsite: a database for the comprehensive investigation of AU-rich elements
JF - Nucleic Acids Research
DO - 10.1093/nar/gkq990
DA - 2011-01-11
UR - https://www.deepdyve.com/lp/oxford-university-press/aresite-a-database-for-the-comprehensive-investigation-of-au-rich-0S0KyDwjVY
SP - D66
EP - D69
VL - 39
IS - suppl_1
DP - DeepDyve
ER -