TY - JOUR
AU - Latchman, D S
AB - Cell Death and Differentiation (2000) 7, 329 ± 330 ã 2000 Macmillan Publishers Ltd All rights reserved 1350-9047/00 $15.00 www.nature.com/cdd Letter to the Editor Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters Dear Editor, The Bcl-2 family of proteins contains at least 15 members members are anchored in the mitochondrial outer membrane, which can have pro- or anti-apoptotic effects. All share at least and anti-apoptotic family members such as Bcl-2 and Bcl-x one of four Bcl-2 homology domains (BH1 to BH4), and form ion channels which increase the rate of proton extrusion inclusion of different BH domains in individual Bcl-2 family from mitochondria. members is generally responsible for pro- or anti-apoptotic Some studies have begun to address the transcriptional activity (reviewed in ). Pro- and anti-apoptotic members can regulation of anti-apoptotic Bcl-2 genes. In leukaemias, for form heterodimers, and their ratio may determine whether a example, a hybrid transcription factor formed by chromo- 2 4 death or survival signal is delivered. There is strong evidence somal rearrangement increases Bcl-2 expression, and that the actions of Bcl-2 proteins are exerted at the level of the overexpression of the CCAAT enhancer binding protein, mitochondrial membrane (reviewed in 
TI - Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters
JF - Cell Death & Differentiation
DO - 10.1038/sj.cdd.4400656
DA - 2000-03-27
UR - https://www.deepdyve.com/lp/springer-journals/opposing-actions-of-stat-1-and-stat-3-on-the-bcl-2-and-bcl-x-promoters-0T0mZeb2eq
SP - 329
EP - 330
VL - 7
IS - 3
DP - DeepDyve
ER -