TY - JOUR
AU - Reinherz, E L
AB - Recent studies suggested that the clonally unique Ti epitopes defined by non-cross-reactive monoclonal antibodies might represent the variable regions of the antigen receptor. Here we determine whether such anti-Ti antibodies could trigger clonal T cell activation. Anticlonotypic monoclonal antibodies to the 49/43-kdalton heterodimer of a given clone or antibodies to the 20/25-kdalton membrane associated monomorphic T3 molecule selectively induce proliferation and IL-2 secretion when linked to a solid support. In contrast, anti-T4 and anti-T8 antibodies under the same conditions have no effect. In conclusion, these results imply that anticlonotypic antibody functions in a fashion analogous to antigen and further support the notion that the T3-Ti molecular complex represents the antigen receptor on human T lymphocytes.
TI - Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.
JF - The Journal of Experimental Medicine
DO - 10.1084/jem.158.3.988
DA - 1983-09-01
UR - https://www.deepdyve.com/lp/rockefeller-university-press/antigen-like-effects-of-monoclonal-antibodies-directed-at-receptors-on-0cWqTNcamy
SP - 988
VL - 158
IS - 3
DP - DeepDyve
ER -