TY - JOUR
AU - Henikoff, Steven
AB - Although DNA methylation has been actively studied for several decades, the mechanism by which it causes gene silencing remains largely unknown. In contrast to DNA methylation, the histone variant H2A.Z promotes transcriptional competence in plants, animals and fungi. This paper reports the finding that regions of DNA methylation in the Arabidopsis thaliana genome are deficient in H2A.Z. DNA methylation appears to repress transcription by exclusion of H2A.Z. This suggets a novel relationship between a covalent modification of DNA and a core nucleosome component with an important role in organizing eukaryotic chromatin.
TI - Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks
JF - Nature
DO - 10.1038/nature07324
DA - 2008-09-24
UR - https://www.deepdyve.com/lp/springer-journals/histone-h2a-z-and-dna-methylation-are-mutually-antagonistic-chromatin-0ypEv8kUPm
SP - 125
EP - 129
VL - 456
IS - 7218
DP - DeepDyve
ER -