TY - JOUR
AU1 - Villar, Diego
AU2 - Flicek, Paul
AU3 - Odom, Duncan T.
AB - 


Transcription factors orchestrate tissue-specific gene expression and thus tissue identity. Metazoan gene regulation is highly complex, and comparative analyses of transcription factor binding across species have revealed mechanisms underlying both genome evolution and gene regulation.


Early studies focused on individual loci and showed both conservation and divergence of putative transcription factor binding sites across metazoan species.


Direct global mapping of transcription factor binding locations in multiple mammalian and fruitfly species revealed that tissue-specific transcription factor binding evolves rapidly in mammals, whereas developmental transcription factor binding in fruitflies seems to be under substantially greater constraint.


Comparative studies in mammals and fruitflies have also highlighted common properties of metazoan transcription factor binding evolution, such as dependence on genetic sequence changes, combinatorial co-evolution of binding and partially compensatory turnover.


Observed differences in transcription factor binding evolution and densities of conserved non-coding elements among different metazoan families might be the result of different pressures from extreme differences in effective population sizes.


In mammals, cross-species chromatin immunoprecipitation followed by sequencing studies have further revealed how transposable element-derived sequences help to generate novel lineage-specific transcription factor binding.



TI - Evolution of transcription factor binding in metazoans — mechanisms and functional implications
JF - Nature Reviews Genetics
DO - 10.1038/nrg3481
DA - 2014-03-04
UR - https://www.deepdyve.com/lp/springer-journals/evolution-of-transcription-factor-binding-in-metazoans-mechanisms-and-1KsQZFoZMv
SP - 221
EP - 233
VL - 15
IS - 4
DP - DeepDyve
ER -