TY - JOUR
AU - Eichhammer, Peter
AB - ORIGINAL ARTICLE Effects of Intranasal Oxytocin on Thermal Pain in Healthy Men: A Randomized Functional Magnetic Resonance Imaging Study Matthias Zunhammer, PhD, Sandra Geis, MSc, Volker Busch, MD, Mark W. Greenlee, PhD, and Peter Eichhammer, MD ABSTRACT Objective: Intranasal oxytocin has been shown to affect human social and emotional processing, but its potential to affect pain remains elusive. This randomized, placebo-controlled, double-blind, crossover trial investigated the effect of intranasal oxytocin on the perception and processing of noxious experimental heat in 36 healthy male volunteers. Methods: Thermal thresholds were determined according to the Quantitative Sensory Testing protocol. A functional magnetic resonance imaging experiment including intensity and unpleasantness ratings of tonic heat was used to investigate the effects of oxytocin within the brain. Results: Thirty men (aged 18–50 years) were included in the study. Intranasal oxytocin had no significant effect on thermal thresholds, but significantly (t = −2.06, p = .046) reduced heat intensity ratings during functional magnetic resonance imag- ing. The effect on intensity ratings was small (−3.46 points on a 100-point visual analog scale [95% confidence interval {CI} = −6.86 to −0.07] and independent of temperature. No effects of oxytocin on stimulus- or temperature-related process- ing were found at 
TI - Effects of Intranasal Oxytocin on Thermal Pain in Healthy Men  A Randomized Functional Magnetic Resonance Imaging Study
JF - Psychosomatic Medicine
DO - 10.1097/PSY.0000000000000142
DA - 2015-02-01
UR - https://www.deepdyve.com/lp/wolters-kluwer-health/effects-of-intranasal-oxytocin-on-thermal-pain-in-healthy-men-a-1gcte0e2D0
SP - 156–166-156&ndash
EP - ndash;166-156–166
VL - 77
IS - 2
DP - DeepDyve
ER -