TY - JOUR
AU - 
AB - REVIEW ARTICLE published: 17 November 2014 doi: 10.3389/fimmu.2014.00553 IL-1 receptor-associated kinase signaling and its role in inflammation, cancer progression, and therapy resistance 1 2 2,3 Ajay Jain *, Sabina Kaczanowska and Eduardo Davila * Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, State University of New York Upstate Medical University, Albany, NY, USA Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA Greenebaum Cancer Center, Baltimore, MD, USA Edited by: Chronic inflammation has long been associated with the development of cancer. Among Anton G. Kutikhin, Russian Academy the various signaling pathways within cancer cells that can incite the expression of inflam- of Medical Sciences, Russia matory molecules are those that activate IL-1 receptor-associated kinases (IRAK). The IRAK Reviewed by: family is comprised of four family members, IRAK-1, IRAK-2, IRAK-3 (also known as IRAK- Bernhard H. Rauch, University M), and IRAK-4, which play important roles in both positively and negatively regulating Medicine Greifswald, Germany Haiqi He, US Department of the expression of inflammatory molecules. The wide array of inflammatory molecules that Agriculture, USA are expressed in response to IRAK signaling within the tumor microenvironment regulate *Correspondence: the production of factors which promote tumor growth, 
TI - IL-1 Receptor-Associated Kinase Signaling and Its Role in Inflammation, Cancer Progression, and Therapy Resistance
JF - Frontiers in Immunology
DO - 10.3389/fimmu.2014.00553
DA - 2014-11-17
UR - https://www.deepdyve.com/lp/unpaywall/il-1-receptor-associated-kinase-signaling-and-its-role-in-inflammation-1sl6owcXB7
DP - DeepDyve
ER -