TY - JOUR
AU - 
AB - Hindawi Publishing Corporation PPAR Research Volume 2008, Article ID 134059, 15 pages doi:10.1155/2008/134059 Review Article PPARs Mediate Lipid Signaling in Inflammation and Cancer Liliane Michalik and Walter Wahli Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, 1015 Lausanne, Switzerland Correspondence should be addressed to Liliane Michalik, liliane.michalik@unil.ch and Walter Wahli, walter.wahli@unil.ch Received 6 August 2008; Accepted 17 September 2008 Recommended by Dipak Panigrahy Lipid mediators can trigger physiological responses by activating nuclear hormone receptors, such as the peroxisome proliferator- activated receptors (PPARs). PPARs, in turn, control the expression of networks of genes encoding proteins involved in all aspects of lipid metabolism. In addition, PPARs are tumor growth modifiers, via the regulation of cancer cell apoptosis, proliferation, and differentiation, and through their action on the tumor cell environment, namely, angiogenesis, inflammation, and immune cell functions. Epidemiological studies have established that tumor progression may be exacerbated by chronic inflammation. Here, we describe the production of the lipids that act as activators of PPARs, and we review the roles of these receptors in inflammation and cancer. Finally, we consider emerging strategies for therapeutic intervention. Copyright © 2008 L. Michalik and W. Wahli. This is an open access 
TI - PPARs Mediate Lipid Signaling in Inflammation and Cancer
JF - PPAR Research
DO - 10.1155/2008/134059
DA - 2008-01-01
UR - https://www.deepdyve.com/lp/unpaywall/ppars-mediate-lipid-signaling-in-inflammation-and-cancer-2H7Fo0oET2
DP - DeepDyve
ER -