TY - JOUR
AU - Adan, R
AB - International Journal of Obesity (2014) 38, 610–618 & 2014 Macmillan Publishers Limited All rights reserved 0307-0565/14 www.nature.com/ijo ORIGINAL ARTICLE GHS-R1a signaling in the DMH and VMH contributes to food anticipatory activity M Merkestein, MA van Gestel, EM van der Zwaal, MA Brans, MC Luijendijk, AJ van Rozen, J Hendriks, KM Garner, AJ Boender, R Pandit and R Adan BACKGROUND: Rats that have restricted access to food at a fixed time point of the circadian phase display high levels of food anticipatory activity (FAA). The orexigenic hormone ghrelin has been implicated in the regulation of FAA. However, it is not known via which brain area ghrelin exerts this effect. Growth hormone secretagogue receptor 1a (GHS-R1a) is highly expressed in the hypothalamus, including the dorsomedial hypothalamus (DMH) and the ventromedial hypothalamus (VMH). These two hypothalamic areas have been reported to play a role in FAA. AIM OF THE STUDY: To examine the role of GHS-R1a signaling in the DMH and VMH in FAA. DESIGN: Adeno-associated virus expressing a shRNA directed against GHS-R1a was used to establish local knockdown of GHS-R1a in the DMH and VMH in rats. Rats were subsequently subjected to a restricted feeding schedule (RFS). RESULTS: Under ad libitum 
TI - GHS-R1a signaling in the DMH and VMH contributes to food anticipatory activity
JF - International Journal of Obesity
DO - 10.1038/ijo.2013.131
DA - 2013-07-25
UR - https://www.deepdyve.com/lp/springer-journals/ghs-r1a-signaling-in-the-dmh-and-vmh-contributes-to-food-anticipatory-2IDXtskLfc
SP - 610
EP - 618
VL - 38
IS - 4
DP - DeepDyve
ER -