TY - JOUR
AU - Starr, Arnold
AB - Abstract • The P3 component of both auditoryevent—and visual-event—related potentials of 13 patients with Huntington's disease was studied and compared with the P3 component of normal patients. The latencies of the patients' P3 components were compared with the latency-age regression lines generated by the normal population in both modalities. A P3 latency was considered abnormal if it fell above the 2-SE limit for the latency-age regression line. The incidence of normal or abnormal P3 latencies in the two modalities was compared with the results of computed tomography, electroencephalography, and neuropsychological testing. Nine patients had abnormal P3 latencies and ten patients had abnormal visual P3 latencies, with seven having abnormal latencies on both tests and 12 having abnormal latencies on one of the two tests. An abnormal P3 latency in one modality did not imply an abnormal P3 latency in the other. An abnormality of the P3 latency did not correlate with an abnormality in results from computed tomography, electroencephalography, or neuropsychological testing. References 1. Hillyard SA, Kutas M: Electrophysiology of cognitive processing . Ann Rev Psychol 1983; 34:33-61.Crossref 2. Donchin E: Event related brain potentials , in Begleiter H (ed): Evoked Brain Potentials and Behavior . New York, Plenum Publishing Corp, 1979, pp 13-88. 3. Courchesne E: Changes in P3 waves with event repetition: Long-term effects on scalp distribution and amplitude . Electroencephalogr Clin Neurophysiol 1978;46:754-766.Crossref 4. Sutton S: P300 13 years later , in Begleiter H (ed): Evoked Brain Potentials and Behavior . New York, Plenum Publishing Corp, 1979, pp 107-126. 5. Goodin DS, Squires KC, Henderson BH, et al: Age related variations in evoked potentials to auditory stimuli in normal human subjects . Electroencephalogr Clin Neurophysiol 1978;44:447-458.Crossref 6. Hansch EC, Syndulko K, Cohen ZI, et al: Cognition in Parkinson's disease: An event-related potential perspective . Ann Neurol 1982;11:599-607.Crossref 7. Pfefferbaum A, Wenegrat BG, Ford JM, et al: Clinical application of the P3 component of event-related potentials: II. Dementia, depression and schizophrenia . Electroencephalogr Clin Neurophysiol 1984;59:104-124.Crossref 8. Picton TW, Stuss DT, Champagne SC, et al: The effects of age on human event-related potentials . Psychophysiology 1984;21:312-325.Crossref 9. Paulson GW: Diagnosis of Huntington's disease . Adv Neurol 1979;23:177-184. 10. Klawans HL, Goetz CG, Perlik S: Presymptomatic and early detection in Huntington's disease . Ann Neurol 1980;8:343-347.Crossref 11. Lyle OE, Gottesman II: Subtle cognitive deficits as 15 to 20 year precursors of Huntington's disease . Adv Neurol 1979;23:227-238. 12. Syndulko K, Hansch EC, Cohen SN, et al: Long-latency event related potentials in normal aging and dementia , in Courjon J, Maugierer F, Revol M (eds). Clinical application of Evoked Potentials in Neurology . New York, Raven Press, 1981, pp 279-286. 13. Brown WS, Marsh JT, LaRue A: Expotential electrophysiological aging: P3 latency . Electroencephalogr Clin Neurophysiol 1983;55:227-285.Crossref 14. Shoulson I, Chase TN: Huntington's disease . Ann Rev Med 1975;26:419-436.Crossref
TI - Cognitive Evoked Potentials (P300) in Early Huntington's Disease
JF - Archives of Neurology
DO - 10.1001/archneur.1985.04060090066016
DA - 1985-10-01
UR - https://www.deepdyve.com/lp/american-medical-association/cognitive-evoked-potentials-p300-in-early-huntington-s-disease-2S2IcgwOEn
SP - 984
EP - 987
VL - 42
IS - 10
DP - DeepDyve
ER -