TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 271, No. 10, Issue of March 8, pp. 5513–5518, 1996 © 1996 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. (Received for publication, October 2, 1995, and in revised form, December 4, 1995) Birgitte Smith-Sørensen‡, E. Marielle Hijmans, Roderick L. Beijersbergen, and Rene´ Bernards§ From the Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands The c-myc gene encodes a sequence-specific DNA bind- specific DNA binding site (CACGTG) has been identified for the ing protein that activates transcription of cellular complex (Blackwell et al., 1990; Blackwood and Eisenman, genes. Transcription activation by Myc proteins is reg- 1991; Blackwood et al., 1992; Halazonetis and Kandil, 1991; ulated by phosphorylation of serine and threonine res- Prendergast and Ziff, 1991). A strong and highly conserved idues within the transactivation domain and by complex transcriptional activation domain is located within the amino formation with the retinoblastoma-related protein p107. terminus of Myc proteins (Kato et al., 1990). Importantly, both In Burkitt’s lymphoma, missense mutations within the the transactivation domain and the DNA binding domain are c-Myc transactivation domain have been found with required for transformation (Stone et 
TI - Functional Analysis of Burkitt's Lymphoma Mutant c-Myc Proteins
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.271.10.5513
DA - 1996-03-01
UR - https://www.deepdyve.com/lp/unpaywall/functional-analysis-of-burkitt-s-lymphoma-mutant-c-myc-proteins-2a8wTja6Y0
DP - DeepDyve
ER -