TY - JOUR
AU1 - Ohta, Keisuke
AU2 - Matsumoto, Yusuke
AU3 - Nishio, Machiko
AB - We previously found that infection with human parainfluenza virus type 2 (hPIV-2), a member of the genus Orthorubulavirus, family Paramyxoviridae, causes filamentous actin (F-actin) formation to promote viral growth. In the present study, we investigated whether similar regulation of F-actin formation is observed in infections with other rubulaviruses, such as parainfluenza virus type 5 (PIV-5) and simian virus 41 (SV41). Infection with these viruses caused F-actin formation and RhoA activation, which promoted viral growth. These results indicate that RhoA-induced F-actin formation is important for efficient growth of these rubulaviruses. Only SV41 and hPIV-2 V and P proteins bound to Graf1, while the V and P proteins of PIV-5, mumps virus, and hPIV-4 did not bind to Graf1. In contrast, the V proteins of these rubulaviruses bound to both inactive RhoA and profilin 2. These results suggest that there are common and unique mechanisms involved in regulation of F-actin formation by members of the genus Orthorubulavirus.
TI - Common and unique mechanisms of filamentous actin formation by viruses of the genus Orthorubulavirus
JF - Archives of Virology
DO - 10.1007/s00705-020-04565-y
DA - 2020-04-25
UR - https://www.deepdyve.com/lp/springer-journals/common-and-unique-mechanisms-of-filamentous-actin-formation-by-viruses-2bEuvdBn4g
SP - 799
EP - 807
VL - 165
IS - 4
DP - DeepDyve
ER -