TY - JOUR
AU - 
AB - The Journal of Neuroscience, August 15, 2002, 22(16):6846–6855 Serotonin Receptor Activation Inhibits Sodium Current and Dendritic Excitability in Prefrontal Cortex via a Protein Kinase C-Dependent Mechanism 1,3 2,3 1,3 2,3 1,3 David B. Carr, Donald C. Cooper, Sasha L. Ulrich, Nelson Spruston, and D. James Surmeier 1 2 3 Department of Physiology, Department of Neurobiology and Physiology, and Institute for Neuroscience, Northwestern University, Chicago, Illinois 60611 The serotonin (5-HT) innervation of the prefrontal cortex (PFC) tion voltage dependence. These effects were mediated by G exerts a powerful modulatory influence on neuronal activity in activation of phospholipase C, leading to activation of protein this cortical region, although the mechanisms through which kinase C (PKC). 5-HT receptor stimulation also reduced the 2a/c 5-HT modulates cellular activity are unclear. Voltage-dependent amplitude of persistent Na current without altering its activa- Na channels are one potential target of 5-HT receptor signal- tion voltage dependence. This modulation was also mediated ing that have wide-ranging effects on activity. Molecular and by PKC. Although 5-HT receptor activation did not affect 2a,c electrophysiological studies were used to test this potential somatic action potentials of layer V pyramidal neurons in PFC linkage. Single cell RT-PCR profiling revealed that the 
TI - Serotonin Receptor Activation Inhibits Sodium Current and Dendritic Excitability in Prefrontal Cortex via a Protein Kinase C-Dependent Mechanism
JO - The Journal of Neuroscience
DO - 10.1523/jneurosci.22-16-06846.2002
DA - 2002-08-15
UR - https://www.deepdyve.com/lp/unpaywall/serotonin-receptor-activation-inhibits-sodium-current-and-dendritic-304Lwju00B
DP - DeepDyve
ER -