TY - JOUR
AU - Rodan, Gideon A.
AB - JOURNAL OF BONE AND MINERAL RESEARCH Volume 6, Number 6, 1991 Mary Ann Liebert, Inc., Publishers Perspectives Mechanical Loading, Estrogen Deficiency, and the Coupling of Bone Formation to Bone Resorption GIDEON A. RODAN tention (bone formation). Baylink and colleagues(14’ pro- INTRODUCTION posed that a growth factor, possibly insulin-like growth factor (IGF) 11, is released during bone resorption and STUDY BY NOTELOVITZ et al. (page 583) suggests that stimulates bone formation. Thk, hypothesis and those dis- A estrogen is necessary for the beneficial effects of cussed here are not mutually exclusive. bone - loading exercises on bone mineral density. The cel- The dependence of coupling cn mechanical stimuli is ap- lular and molecular mechanisms for mechanical and estro- parent primarily in cancellous bone,‘’5) where immobiliza- gen effects on bone are poorly understood, but several tion increases bone resorption and bone formation is sub- working hypotheses can be formulated on the basis of re- cent literature. The observations of Notelovitz et al. are stantially decreased.(’b-211 Similar uncoupling, associated with a lack of mechanical strain, was also observed in hu- consistent with previous findings by the same and other authors showing that weight-bearing exercises did not in- man trabecular bone, in which 
TI - Perspectives: Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption
JF - Journal of Bone and Mineral Research
DO - 10.1002/jbmr.5650060602
DA - 1991-06-01
UR - https://www.deepdyve.com/lp/oxford-university-press/perspectives-mechanical-loading-estrogen-deficiency-and-the-coupling-3AsiMDv2A3
SP - 527
EP - 530
VL - 6
IS - 6
DP - DeepDyve
ER -