TY - JOUR
AU - Rebaï, A
AB - Abstract We describe a method for constructing the confidence interval of the QTL location parameter. This method is developed in the local asymptotic framework, leading to a linear model at each position of the putative QTL. The idea is to construct a likelihood ratio test, using statistics whose asymptotic distribution does not depend on the nuisance parameters and in particular on the effect of the QTL. We show theoretical properties of the confidence interval built with this test, and compare it with the classical confidence interval using simulations. We show in particular, that our confidence interval has the correct probability of containing the true map location of the QTL, for almost all QTLs, whereas the classical confidence interval can be very biased for QTLs having small effect. This content is only available as a PDF. © Genetics 1994 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - Constructing confidence intervals for QTL location.
JF - Genetics
DO - 10.1093/genetics/138.4.1301
DA - 1994-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/constructing-confidence-intervals-for-qtl-location-3qW0UX9jz3
SP - 1301
EP - 1308
VL - 138
IS - 4
DP - DeepDyve
ER -