TY - JOUR AU - AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 277, No. 52, Issue of December 27, pp. 51017–51024, 2002 © 2002 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. Functional Analysis of Mutations in the  Subunit of AMP-activated Protein Kinase Associated with Cardiac Hypertrophy and Wolff-Parkinson-White Syndrome* Received for publication, July 16, 2002, and in revised form, September 25, 2002 Published, JBC Papers in Press, October 22, 2002, DOI 10.1074/jbc.M207093200 Tyrone Daniel and David Carling‡ From the Cellular Stress Group, MRC Clinical Sciences Centre, Hammersmith Hospital, DuCane Road, London W12 0NN, United Kingdom and two regulatory subunits ( and ) (5, 6) and isoforms of all Mutations in the gene encoding the  subunit of the AMP-activated protein kinase (AMPK) have recently three subunits have been identified (7–9). Although there is been shown to cause cardiac hypertrophy and ventric- compelling evidence indicating that formation of the heterotri- ular pre-excitation (Wolff-Parkinson-White syndrome). meric complex is necessary for significant kinase activity (6, 10) We have examined the effect of four of these mutations the precise role of the regulatory subunits remains unclear. In on AMPK activity. The mutant  polypeptides are all 2 addition, at present our understanding TI - Functional Analysis of Mutations in the γ2 Subunit of AMP-activated Protein Kinase Associated with Cardiac Hypertrophy and Wolff-Parkinson-White Syndrome JF - Journal of Biological Chemistry DO - 10.1074/jbc.m207093200 DA - 2002-12-01 UR - https://www.deepdyve.com/lp/unpaywall/functional-analysis-of-mutations-in-the-2-subunit-of-amp-activated-3u5ku2PF3T DP - DeepDyve ER -