TY - JOUR
AU - Farrow, Stuart N
AB - WSL‐1/TRAMP (DR3) is a member of the tumour necrosis factor (TNF) receptor superfamily which exhibits effects on NF‐κB activation and apoptosis. TWEAK, a novel TNF‐related molecule, has been proposed as the ligand for this receptor. Utilising both human and murine TWEAK ligand, it is shown that TWEAK and WSL‐1/TRAMP do not interact in an in vitro binding assay and that TWEAK binds strongly to cells that do not express WSL‐1/TRAMP on the cell surface. Biological activity of TWEAK is also observed in these cells. Finally, cells isolated from WSL‐1/TRAMP knockout mice are shown to retain their ability to interact with TWEAK. These results suggest that WSL‐1/TRAMP is not the major receptor for TWEAK
TI - Studies on the interaction between TWEAK and the death receptor WSL‐1/TRAMP (DR3)
JF - Febs Letters
DO - 10.1016/S0014-5793(00)02219-5
DA - 2000-11-24
UR - https://www.deepdyve.com/lp/wiley/studies-on-the-interaction-between-tweak-and-the-death-receptor-wsl-1-4f6CFrILgu
SP - 135
EP - 141
VL - 485
IS - 2-3
DP - DeepDyve
ER -