TY - JOUR
AU - Adnot, Serge
AB - Abstract Angiogenic factors exert protective effects on the lung. To investigate the effect of VEGF-B, a factor coexpressed in the lung with VEGF-A, we assessed chronic hypoxic pulmonary hypertension in VEGF-B knockout mice (VEGF-B−/−) and in rats with lung overexpression of VEGF-B induced by adenovirus transfer. No significant difference in pulmonary hemodynamics, right ventricular hypertrophy, distal vessel muscularization, or vascular density was found between VEGF-B−/− and control mice after 3 wk of hypoxia. When overexpressed, VEGF-B 167 or VEGF-B 186 had protective effects similar to those of human VEGF-A 165 . Lung endothelial nitric oxide synthase (eNOS) expression was increased by 5 days of hypoxia or VEGF-A adenovirus vector (Ad.VEGF-A) overexpression, whereas VEGF-B 167 or VEGF-B 186 had no effect. With hypoxia or normoxia, the wet-to-dry lung weight ratio was increased 5 days after Ad.VEGF-A administration compared with control (Ad.nul), Ad.VEGF-B 167 , or Ad.VEGF-B 186 . Endogenous VEGF-B does not counteract the development of hypoxic pulmonary hypertension. However, when overexpressed in the lung, VEGF-B can be as potent as VEGF-A in attenuating pulmonary hypertension, although it has no effect on eNOS expression or vascular permeability. adenoviral transfer angiogenic factors Footnotes This work was supported in part by the nonprofit organization Association Française des Myopathies. Address for reprint requests and other correspondence: S. Adnot, INSERM U492, Faculté de Médecine, 8 Rue du Général Sarrail, 94010 Creteil, France (E-mail: serge.adnot@hmn.ap-hop-paris.fr ). The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “ advertisement ” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. First published January 24, 2003;10.1152/ajplung.00247.2002 Copyright © 2003 the American Physiological Society
TI - Role of VEGF-B in the lung during development of chronic hypoxic pulmonary hypertension
JF - AJP - Lung Cellular and Molecular Physiology
DO - 10.1152/ajplung.00247.2002
DA - 2003-06-01
UR - https://www.deepdyve.com/lp/the-american-physiological-society/role-of-vegf-b-in-the-lung-during-development-of-chronic-hypoxic-4pObOUN3KM
SP - L926
VL - 284
IS - 6
DP - DeepDyve
ER -