TY - JOUR AU - AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 40, Issue of October 1, pp. 41775–41782, 2004 © 2004 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. Phosphorylation of the Platelet-derived Growth Factor Receptor- by G Protein-coupled Receptor Kinase-2 Reduces Receptor Signaling and Interaction with the Na /H Exchanger Regulatory Factor* Received for publication, March 24, 2004, and in revised form, June 23, 2004 Published, JBC Papers in Press, July 22, 2004, DOI 10.1074/jbc.M403274200 Kerry L. Hildreth‡§, Jiao-Hui Wu‡, Larry S. Barak , Sabrina T. Exum‡, Luke K. Kim‡§, Karsten Peppel‡, and Neil J. Freedman‡ From the Departments of ‡Medicine (Cardiology) and Cell Biology, Duke University Medical Center, Durham, North Carolina 27710 tenance of mesenchymal cells, and in pathologic proliferative G protein-coupled receptor kinase-2 (GRK2) can phos- phorylate and desensitize the platelet-derived growth fac- processes like malignant neoplasia (1, 2) and atherosclerosis tor receptor- (PDGFR) in heterologous cellular systems. (3–5). Maintaining cellular homeostasis and bridling neoplasia To determine whether GRK2 regulates the PDGFR in therefore requires precise regulation of signaling through this physiologic systems, we examined PDGFR signaling in receptor protein tyrosine kinase. Mechanisms described thus mouse embryonic fibroblasts from GRK2-null and cognate far for TI - Phosphorylation of the Platelet-derived Growth Factor Receptor-β by G Protein-coupled Receptor Kinase-2 Reduces Receptor Signaling and Interaction with the Na+/H+ Exchanger Regulatory Factor JF - Journal of Biological Chemistry DO - 10.1074/jbc.m403274200 DA - 2004-10-01 UR - https://www.deepdyve.com/lp/unpaywall/phosphorylation-of-the-platelet-derived-growth-factor-receptor-by-g-4vnGJWaTwq DP - DeepDyve ER -