TY - JOUR
AU - Geerlings, Mirjam I
AB - Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Background: The biological underpinnings of the relationship between depression Netherlands and dementia are currently not completely understood. Previous research has high- Utrecht University, Utrecht, Netherlands lighted the role of vascular, metabolic, inflammatory, and stress markers in the role Faculty of Medicine, University of Iceland, Reykjavik, Iceland of both depression and dementia. Allostatic load has been an all-encompassing term National Institute on Aging, Baltimore, MD, to describe these biological factors when investigating subgroups in individuals based USA on health characteristics. The current study aimed to elucidate if depression subtypes National Institute on Aging, Laboratory for exist based on modifiable allostatic load factors using latent class analysis (LCA), and Epidemiology and Population Sciences, Baltimore, MD, USA whether these subtypes have differing risk on incident all-cause dementia, Alzheimer’s disease (AD), and non-AD diagnosis using Cox regression analyses. Correspondence Emma L Twait, Julius Center for Health Sci- Method: The study included 5343 individuals without dementia at baseline from the ences and Primary Care, University Medi- AGES-Reykjavik Study. Vascular factors (systolic blood pressure and pulse pressure), cal Center Utrecht and Utrecht University, Utrecht, Netherlands cholesterol (high-density lipoprotein and low-density lipoprotein), metabolic factors Email: E.L.Twait@umcutrecht.nl 
TI - Late‐life depression, allostatic load, and risk of dementia: The AGES‐Reykjavik study
JF - Alzheimer s & Dementia
DO - 10.1002/alz.053855
DA - 2021-12-01
UR - https://www.deepdyve.com/lp/wiley/late-life-depression-allostatic-load-and-risk-of-dementia-the-ages-50WomJuDfH
VL - 17
IS - S10
DP - DeepDyve
ER -