TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 272, No. 39, Issue of September 26, pp. 24113–24116, 1997 Communication © 1997 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. imately 30% of human cancers, lead to chronic GTP binding, Oncogenic Ha-Ras-induced which initiates the activation of signal transduction cascades. Signaling Activates NF-kB In this regard, Ras is known to stimulate both the Raf/MEK / ERK pathway as well as the MEKK/SEK/JNK pathway (3–7). Transcriptional Activity, Which Activation of these and other protein kinase cascades (8 –10) is Is Required for Cellular critical for the ability of Ras to exert both its normal and oncogenic functions. The ultimate targets of the Ras-induced Transformation* signal transduction pathways are transcription factors (see Ref. 4), which regulate the expression of genes involved in (Received for publication, June 16, 1997, and in revised form, proliferation and oncogenesis. Two transcription factors, Ets July 22, 1997) and c-Jun, have been shown to be essential for Ras-induced Timothy S. Finco‡§¶, John K. Westwick‡i**, gene expression and for Ras-mediated cell transformation in Jacqueline L. Norris‡ ‡‡, Amer A. Beg§§, vitro and tumorigenesis (11, 12). In these cases, Ras-induced Channing J. Der‡§i, and signaling pathways activate 
TI - Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.272.39.24113
DA - 1997-09-01
UR - https://www.deepdyve.com/lp/unpaywall/oncogenic-ha-ras-induced-signaling-activates-nf-b-transcriptional-5L9vmvN4cH
DP - DeepDyve
ER -