TY - JOUR AB - Eur Radiol Suppl (2004) 14[Suppl 8]:P110–P115 DOI 10.1007/s10406-004-0086-1 © Springer-Verlag 2004 Adrian Lim David Cosgrove Abstract For the first time, func- the true transit time. Similar timing A. Lim · D.O. Cosgrove tional studies with ultrasound have measurements have proved particu- Imaging Sciences Department, Imperial College, been made possible by the introduc- larly useful for measuring the porto- Charing Cross and Hammersmith Hospitals, tion of microbubble contrast agents. systemic shunts that are a feature of London, UK That they are confined to the circu- liver metastases and cirrhosis. D.O. Cosgrove ( ) lation and that the small volume A unique feature of microbubble Radiology Department, boluses that are effective are particu- contrast agents is their fragility when Hammersmith Hospital, lar advantages when compared to insonated at higher (but still permis- Du Cane Road, London W12 0HS, UK iodinated and gadolinium-based sible) powers. This can be used to E-mail: d.cosgrove@imperial.ac.uk agents. Classical indicator dilution create a negative bolus and the reper- calculations can be applied to the fusion of a slice of tissue can then transit curves that can be measured be followed. From the exponential as the contrast washes into and out refill curve, features that relate to of TI - Functional studies JF - European Radiology Supplements DO - 10.1007/s10406-004-0086-1 DA - 2004-01-01 UR - https://www.deepdyve.com/lp/springer-journals/functional-studies-5VA8jwBvO7 SP - P110 EP - P115 VL - 14 IS - 8 DP - DeepDyve ER -