TY - JOUR
AU - Cotman, C W
AB - Transforming growth factor-beta (TGF-beta) is a major modulator of the extracellular matrix and cell growth, and shows affinity for and interaction with several substances present in plaques in Alzheimer's disease (AD). In order to examine a possible role of TGF-beta in plaque biogenesis, we studied its distribution in the limbic system of AD and Down's syndrome (DS) brains. Select plaques displayed TGF-beta 1 immunoreactivity in AD and DS. TGF-beta 1 plaques were mainly located in the molecular layer of the dentate gyrus in AD, while in DS TGF-beta 1 plaques were preferentially located in the entorhinal cortex. In AD, TGF-beta 1 immunoreactivity was also shown in neurofibrillary tangles. The presence of TGF-beta 1 in plaques suggests that TGF-beta 1 may play a role in the cascade of events leading to plaque formation.
TI - Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies.
JF - Neuroreport
DO - 10.1097/00001756-199301000-00018
DA - 1993-04-16
UR - https://www.deepdyve.com/lp/pubmed/transforming-growth-factor-beta-1-is-in-plaques-in-alzheimer-and-down-5esjDqmOeF
SP - 69
EP - 72
VL - 4
IS - 1
DP - DeepDyve
ER -