TY - JOUR
AU1 - Wilson, Sylvia H.
AU2 - Hellman, Kevin M.
AU3 - James, Dominika
AU4 - Adler, Adam C.
AU5 - Chandrakantan, Arvind
AB - Purpose of the ReviewHyperalgesia may be an iatrogenic consequence of surgery or pain management. Thus, it is essential for anesthesiologists, pain management specialists, surgeons, and primary care physicians to regularly update their awareness and strategies for addressing this problem. This educational review of hyperalgesia provides up-to-date knowledge of the contributing mechanisms, differential diagnoses, and medical therapy. A particular focus is placed on common types of postoperative hyperalgesia and recent evidence that anesthesiologists and surgeons should be aware of.Recent FindingsHyperalgesia may acutely manifest due to tissue injury and peripheral sensitization; it can progress to a chronic condition developing from central nervous system sensitization. While clinical evaluation begins with a detailed history, physical examination, and sensory testing, an improved understanding of the clinical and cellular mechanisms involved in hyperalgesia pathology continues to drive future research and advance our understanding of this complex presentation.SummaryOpioid-induced hyperalgesia may be confused with opioid tolerance and withdrawal and must also be differentiated from other diagnoses to optimize patient management and promote disease regression. Hyperalgesia is a common clinical condition with evolving guidelines for testing and treatment. Opioid-induced hyperalgesia is a potential cause of hyperalgesia and must be differentiated to optimize therapeutic decision-making.
TI - Mechanisms, Diagnosis, and Medical Management of Hyperalgesia: an Educational Review
JF - Current Anesthesiology Reports
DO - 10.1007/s40140-021-00485-y
DA - 2021-12-01
UR - https://www.deepdyve.com/lp/springer-journals/mechanisms-diagnosis-and-medical-management-of-hyperalgesia-an-5sQxOAE6uH
SP - 524
EP - 540
VL - 11
IS - 4
DP - DeepDyve
ER -