TY - JOUR
AU - 
AB - REVIEW ARTICLE published: 26 August 2014 doi: 10.3389/fmicb.2014.00450 Suppression of APOBEC3-mediated restriction of HIV-1 by Vif Yuqing Feng, Tayyba T. Baig, Robin P. Love and Linda Chelico* Department of Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada Edited by: The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able Nadine Laguette, Centre National de to suppress replication of viruses with a single-stranded DNA intermediate by inducing la Recherche Scientifique, France mutagenesis and functional inactivation of the virus. Of the seven human APOBEC3 Reviewed by: enzymes, only APOBEC3-D, -F, -G, and -H appear relevant to restriction of HIV-1 in CD4+ T Atsushi Koito, Kumamoto University, cells and will be the focus of this review. The restriction of HIV-1 occurs most potently Japan Yoshitaka Sato, Nagoya University in the absence of HIV-1 Vif that induces polyubiquitination and degradation of APOBEC3 Graduate School of Medicine, Japan enzymes through the proteasome pathway. To restrict HIV-1, APOBEC3 enzymes must *Correspondence: be encapsidated into budding virions. Upon infection of the target cell during reverse Linda Chelico, Department of transcription of the HIV-1 RNA into (−)DNA, APOBEC3 enzymes deaminate cytosines Microbiology and Immunology, to form uracils in single-stranded (−)DNA 
TI - Suppression of APOBEC3-mediated restriction of HIV-1 by Vif
JF - Frontiers in Microbiology
DO - 10.3389/fmicb.2014.00450
DA - 2014-08-26
UR - https://www.deepdyve.com/lp/unpaywall/suppression-of-apobec3-mediated-restriction-of-hiv-1-by-vif-6E1xPFUqdh
DP - DeepDyve
ER -