TY - JOUR
AU - Abernethy, D R
AB - Advances in systems biology have allowed the development of a highly characterized systems pharmacology model to study mechanisms of drug‐induced hepatotoxicity. In this issue of CPT, Yang et al. describe a model, DILIsym, used to characterize mechanisms of hepatotoxicity of troglitazone. Their modeling approach has provided new insight into troglitazone‐induced hepatotoxicity in humans but is not associated with hepatotoxicity in rats, consistent with preclinical data for this drug.
TI - Application of Systems Pharmacology to Explore Mechanisms of Hepatotoxicity
JF - Clinical Pharmacology & Therapeutics
DO - 10.1038/clpt.2014.167
DA - 2014-11-01
UR - https://www.deepdyve.com/lp/wiley/application-of-systems-pharmacology-to-explore-mechanisms-of-6JK8C0ZIHv
SP - 536
EP - 537
VL - 96
IS - 5
DP - DeepDyve
ER -