TY - JOUR
AU - Kumanogoh, Atsushi
AB - Key PointsSemaphorins were identified originally as repulsive axon-guidance factors during neuronal development. It is becoming increasingly clear that several members of the semaphorin family have roles in the immune system. SEMA4D (CD100), a class IV semaphorin, uses two receptors, plexin-B1 and CD72, the latter of which is a functional lymphocyte receptor. SEMA4D enhances B-cell responses by a unique mechanism — turning off the negative signals of CD72. SEMA4D also has a role in the generation of antigen-specific T cells by enhancing the activation and maturation of professional antigen-presenting cells, such as dendritic cells (DCs). ;Another class IV semaphorin, SEMA4A, which is expressed preferentially by DCs, is involved in T-cell activation. Molecular cloning has shown that the receptor for SEMA4A is TIM2, which is expressed on the surface of activated T cells and belongs to the T-cell, immunoglobulin domain and mucin domain (TIM) protein family. In addition, other semaphorins (such as SEMA3A and SEMA7A) and semaphorin receptors (such as neuropilins) seem to have roles in immune responses.
TI - Semaphorins in interactions between T cells and antigen-presenting cells
JF - Nature Reviews Immunology
DO - 10.1038/nri1003
DA - 2003-02-01
UR - https://www.deepdyve.com/lp/springer-journals/semaphorins-in-interactions-between-t-cells-and-antigen-presenting-6SoF60oviv
SP - 159
EP - 167
VL - 3
IS - 2
DP - DeepDyve
ER -