TY - JOUR
AU - Le Fèvre, Brieuc
AB - The isotope dilution (ID) method requires only the measurement of mass and isotopic mass ratios. For this reason, ID is considered a primary method of analysis, capable of higher precision and accuracy than comparative methods used in conventional instrumental analysis, that are based on calibration relative to reference materials. Compared to thermal ionisation mass spectrometers, inductively coupled plasma source‐mass spectrometers (ICP‐MS) benefit from several practical advantages, including direct liquid sampling at atmospheric pressure, a multi‐element capability, high ionisation efficiency, fast scanning capability and widespread availability. These features greatly improve sample throughput, thereby allowing the isotope dilution method to be used on a routine basis. In turn, ID alleviates the need for quantitative sample handling, and thus makes separation of the analytes from matrix elements much easier. This allows ICP‐MS instruments to be used under optimal conditions, because it is possible to use advanced, high efficiency sample introduction systems without resorting to large dilution factors. Moreover, the cleanliness of the sampling interface and ion optics is preserved, thereby allowing optimum instrumental performance to be maintained for extended periods, so reducing maintenance costs. Examples are given in this review to highlight the potential of isotope dilution combined with analyte separation for achieving high precision in trace element analysis of geochemical samples.
TI - Isotope Dilution with Matrix Element Removal: A Key for High‐Precision, High‐Accuracy Trace Analysis of Geological Samples Using Inductively Coupled Plasma‐Mass Spectrometry
JF - Geostandards & Geoanalytical Research
DO - 10.1111/j.1751-908X.2002.tb00882.x
DA - 2002-07-01
UR - https://www.deepdyve.com/lp/wiley/isotope-dilution-with-matrix-element-removal-a-key-for-high-precision-6T1MvfYZ79
SP - 135
EP - 148
VL - 26
IS - 2
DP - DeepDyve
ER -